Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis

Reinaldo González-Ramos; Anne Van Langendonckt; Sylvie Defrère; Jean‐Christophe Lousse; Jean-Christophe Lousse; Sebastien Colette; Sébastien Colette; Luigi Devoto; Jacques Donnez

doi:10.1016/j.fertnstert.2010.01.013

Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis

Reinaldo González-Ramos, Anne Van Langendonckt, Sylvie Defrère, Jean‐Christophe Lousse, Jean-Christophe Lousse, Sebastien Colette, Sébastien Colette, Luigi Devoto, Jacques Donnez

Fertility and sterility · 2010 · vol. 94(6) , pp. 1985–1994 · doi:10.1016/j.fertnstert.2010.01.013 · PMID:20188363 · W2035214296

review OA: bronze CC0 ⤵ 142 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigates the role of the nuclear factor-κB pathway in the development of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis NF-kappa B Uterine Diseases Animals Endometriosis Endometriosis Endometriosis Endometriosis Female Humans Inflammation Inflammation Models, Biological NF-kappa B NF-kappa B Signal Transduction Signal Transduction Signal Transduction Uterine Diseases Uterine Diseases

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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[1] Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis via openalex

[2] Agents Blocking the Nuclear Factor-κB Pathway Are Effective Inhibitors of Endometriosis in an in vivo Experimental Model via openalex

[3] Angiogenic activity of peritoneal fluid from women with endometriosis via openalex

[4] Antiangiogenic and vascular-disrupting agents in endometriosis: pitfalls and promises via openalex

[5] Apoptosis and the Pathogenesis of Endometriosis via openalex

[6] Apoptosis in human endometrium and endometriosis via openalex

[7] Application of the nuclear factor-κB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study via openalex

[8] Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis via openalex

[9] Circulating Ovarian Steroids and Endometrial Matrix Metalloproteinases (MMPs) via openalex

[10] Combating endometriosis by blocking proteasome and nuclear factor- B pathways via openalex

[11] De novo formation of adhesions in endometriosis: the role of iron and free radical reactions via openalex

[12] Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum via openalex

[13] Dioxin pollution and endometriosis in Belgium via openalex

[14] Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis via openalex

[15] Early-stage endometriosis: adhesion and growth of human menstrual endometrium in nude mice via openalex

[16] Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo via openalex

[17] Emerging drugs in endometriosis via openalex

[18] Endometriosis via openalex

[19] Endometriosis: A Disease of Oxidative Stress? via openalex

[20] Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin via openalex

[21] Endometriotic disease: the role of peritoneal fluid via openalex

[22] ERB-041, a selective ERβ agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-κB activation via openalex

[23] Evolution of medical treatment for endometriosis: back to the roots? via openalex

[24] Experimental endometriosis via openalex

[25] Expression of integrin adhesion molecules in endometrium and endometriosis via openalex

[26] Expression of integrins E-cadherin in cells from menstrual effluent, endometrium, peritoneal fluid, peritoneum, endometriosis via openalex

[27] Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture via openalex

[28] Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions via openalex

[29] Expression of platelet endothelial cell adhesion molecule-1 in red and black endometriotic lesions via openalex

[30] Expression pattern of integrin adhesion molecules in endometriosis and human endometrium via openalex

[31] Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis via openalex

[32] Hepatocyte Growth Factor/Met System Promotes Endometrial and Endometriotic Stromal Cell Invasion via Autocrine and Paracrine Pathways via openalex

[33] Heritability and Molecular Genetic Studies of Endometriosis via openalex

[34] Human chorionic gonadotrophin attenuates NF-κB activation and cytokine expression of endometriotic stromal cells via openalex

[35] Immunoexpression of hepatocyte growth factor and c-Met receptor in the eutopic endometrium predicts the activity of ectopic endometrium via openalex

[36] Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy via openalex

[37] Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis via openalex

[38] Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis via openalex

[39] Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions via openalex

[40] Increase in the Production of Interleukin‐6, Interleukin‐10, and Interleukin‐12 by Lipopolysaccharide‐Stimulated Peritoneal Macrophages from Women with Endometriosis via openalex

[41] Interleukin-10 attenuates TNF-α–induced interleukin-6 production in endometriotic stromal cells via openalex

[42] Involvement of nuclear factor-κB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin-1β in ectopic endometrial cells via openalex

[43] Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model via openalex

[44] Iron overload in the peritoneal cavity of women with pelvic endometriosis via openalex

[45] Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid via openalex

[46] Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor α and interleukin-8 expression via openalex

[47] NF-κB Decoy Oligonucleotides Suppress RANTES Expression and Monocyte Chemotactic Activity via NF-κB Inactivation in Stromal Cells of Ectopic Endometrium via openalex

[48] Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis via openalex

[49] Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex

[50] Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? via openalex

[51] Nuclear factor κB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis via openalex

[52] Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis via openalex

[53] Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. via openalex

[54] Oxidative stress and peritoneal endometriosis via openalex

[55] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[56] Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex

[57] Peroxisome proliferator-activated receptor-γ ligand reduced tumor necrosis factor-α-induced interleukin-8 production and growth in endometriotic stromal cells via openalex

[58] Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis via openalex

[59] Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex

[60] Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex

[61] Reduction of apoptosis and proliferation in endometriosis via openalex

[62] Retrograde menstruation in healthy women and in patients with endometriosis. via openalex

[63] Role of cytokines in endometriosis via openalex

[64] Role of Peritoneal Inflammation in Endometriosis‐associated Infertility via openalex

[65] Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms via openalex

[66] Stimulation of Macrophage Migration Inhibitory Factor Expression in Endometrial Stromal Cells by Interleukin 1, beta Involving the Nuclear Transcription Factor NFκB1 via openalex

[67] Sulindac Suppresses Nuclear Factor-κB Activation and RANTES Gene and Protein Expression in Endometrial Stromal Cells from Women with Endometriosis via openalex

[68] Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. via openalex

[69] TAK1 activation for cytokine synthesis and proliferation of endometriotic cells via openalex

[70] Thalidomide Inhibits Tumor Necrosis Factor-α-Induced Interleukin-8 Expression in Endometriotic Stromal Cells, Possibly through Suppression of Nuclear Factor-κB Activation via openalex

[71] The efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical aproach via openalex

[72] The Epidemiology of Endometriosis via openalex

[73] The peritoneal environment in endometriosis via openalex

[74] The role of iron in the pathogenesis of endometriosis via openalex

[75] Transcriptional expression of survivin and its splice variants in endometriosis via openalex

[76] Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon via openalex

[77] Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex

[78] Tumor necrosis factor-α induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-κB and mitogen-activated protein kinase pathways via openalex

[79] Vascular endothelial growth factor and endometriotic angiogenesis via openalex

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