Luigi Devoto

No ORCID on file · 17 papers in corpus
lab-animal 2017
hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells
Molecular human reproduction ·doi:10.1093/molehr/gax015

STUDY QUESTION: How does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function? SUMMARY ANSWER: hCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1…

other 2017
The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase
Journal of Reproductive Immunology ·doi:10.1016/j.jri.2017.10.046

The control of complement activation within embryo-endometrium environment is critical for embryo survival. Cell evasion from complement attack requires interaction of complement regulatory proteins (CRPs) with cell adhesion αvβ3 integrin. …

observational 2016
Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1: implications for endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.04.002

OBJECTIVE: To evaluate divalent metal transporter-1 (DMT1) expression in healthy women's and endometriosis patients' endometrium and to analyze DMT1 and ferritin light chain (Fn-L) expression modulation by iron overload and IL-1β in endomet…

2016
The endometrial expression and paracrine regulation of complement regulatory protein decay accelerating factor in response to embryo signal human chorionic gonadotropin is impaired in endometria from women with endometriosis
·doi:10.1016/j.fertnstert.2016.07.789
2015
Eutopic endometrium from women with endometriosis exhibits decreased levels of complement decay- accelerating factor and abnormal expression of progesterone receptor during the implantation window
·doi:10.1016/j.placenta.2015.01.430
lab-animal 2014
Iron overload-modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis
Fertility and sterility ·doi:10.1016/j.fertnstert.2014.10.046

OBJECTIVE: To evaluate the effect of iron overload on nuclear factor kappa-B (NF-κB) activation in human endometrial stromal cells (ESCs). DESIGN: Experimental study. SETTING: University hospital research laboratory. PATIENT(S): Ten heal…

other 2013
Complement C3 and decay-accelerating factor expression levels are modulated by human chorionic gonadotropin in endometrial compartments during the implantation window
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719113477486

The control of complement activation in the embryo-maternal environment has been demonstrated to be critical for embryo survival. Complement proteins are expressed in the human endometrium; however, the modulation of this expression by embr…

observational 2013
Endometriosis, endometrium, implantation and fallopian tube
·doi:10.1093/humrep/det211

Study question: To compare the pregnancy rate in patients submitted to FET (Frozen Embryos Transfer) of cleavage stage embryos (Group 1), or at the blastocyst stage (Group 2). Summary answer: Our data showed that the transfer of frozen blas…

review 2012
Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.06.021

OBJECTIVE: To update, analyze, and summarize the literature concerning nuclear factor-kappaB (NF-κB) participation in endometriosis pathophysiology. DESIGN: Review. RESULT(S): Nuclear factor-kappaB is physiologically activated in the huma…

2012
SESSION 34: ENDOMETRIOSIS/ENDOMETRIUM: MOLECULAR AND CELLULAR INSIGHTS 1
·doi:10.1093/humrep/27.s2.33
other 2011
Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-9-14

BACKGROUND: The endometrium is a dynamic tissue whose changes are driven by the ovarian steroidal hormones. Its main function is to provide an adequate substrate for embryo implantation. Using microarray technology, several reports have pro…

observational 2011
Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patients
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.12.006

OBJECTIVE: To evaluate nuclear factor kappaB (NF-κB) activation and NF-κB-p65 subunit activation, immunolocalization, and expression in the endometrium of healthy women and endometriosis patients throughout the menstrual cycle. DESIGN: Pro…

2011
POSTER VIEWING SESSION - ENDOMETRIOSIS, ENDOMETRIUM, IMPLANTATION AND FALLOPIAN TUBE
·doi:10.1093/humrep/26.s1.80
review 2010
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.01.013

OBJECTIVE: To evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis. DESIGN: A literature search was conducted in PubMed to identify all relevant citations. RESULT(S): Our findings highlight the important rol…

lab-animal 2010
Posters * Endometriosis, Endometrium and Implantation
·doi:10.1093/humrep/de.25.s1.242

Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…

2009
Surgical Managment of the Non-Communicating Uterine Horn
·doi:10.1016/j.jmig.2009.08.031
other 1984
Estradiol and progesterone nuclear and cytosol receptors of hydrosalpinx
Fertility and sterility ·doi:10.1016/s0015-0282(16)48144-6

Hydrosalpinx is usually associated with a low intrauterine pregnancy rate following restoration of tubal patency by microsurgery. The biochemical evaluation of pathologic tubes from 11 infertile patients showed the presence of estradiol (E2…