Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding

Ling-Yu Chang; Jing Shan; Xinxin Hou; Xin-Xin Hou; Da-Jin Li; Da‐Jin Li; Xiaoqiu Wang; Xiao-Qiu Wang

doi:10.1016/j.jri.2023.103975

Synergy between Th1 and Th2 responses during endometriosis: A review of current understanding

Ling-Yu Chang, Jing Shan, Xinxin Hou, Xin-Xin Hou, Da-Jin Li, Da‐Jin Li, Xiaoqiu Wang, Xiao-Qiu Wang

Journal of reproductive immunology · 2023 · vol. 158 , pp. 103975 · doi:10.1016/j.jri.2023.103975 · PMID:37331087 · W4379619479

review OA: closed CC0 ⤵ 10 in-corpus citations

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Th1 Cells Th1 Cells Th1 Cells

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[1] Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis via openalex

[2] Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors via openalex

[3] Activated Hippo/Yes-Associated Protein Pathway Promotes Cell Proliferation and Anti-apoptosis in Endometrial Stromal Cells of Endometriosis via openalex

[4] Activation of the CXCL16/CXCR6 Axis by TNF-α Contributes to Ectopic Endometrial Stromal Cells Migration and Invasion via openalex

[5] All-trans retinoic acid inhibits epithelial-to-mesenchymal transition (EMT) through the down-regulation of IL-6 in endometriosis via openalex

[6] Cell proliferation effect of GnRH agonist on pathological lesions of women with endometriosis, adenomyosis and uterine myoma via openalex

[7] Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway via openalex

[8] Clinical immunology<br>Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis via openalex

[9] Co-expression of activating and inhibitory receptors on peritoneal fluid NK cells in women with endometriosis via openalex

[10] Combination of estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine secretion and invasion of endometrial stromal cells via openalex

[11] Co-operation between the AKT and ERK signaling pathways may support growth of deep endometriosis in a fibrotic microenvironment in vitro† via openalex

[12] Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway via openalex

[13] CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway via openalex

[14] Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis via openalex

[15] Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P via openalex

[16] Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10 via openalex

[17] Dual inhibition of ERK1/2 and AKT pathways is required to suppress the growth and survival of endometriotic cells and lesions via openalex

[18] Effect of Wnt/β-catenin signal pathway on of matrix metalloproteinase-7 and vascular endothelial growth factor gene expressions in endometriosis via openalex

[19] Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues via openalex

[20] Expression of monocyte chemotactic protein 2 and tumor necrosis factor alpha in human normal endometrium and endometriotic tissues via openalex

[21] Expression of Th1 and Th2 cytokine-associated transcription factors, T-bet and GATA-3, in the eutopic endometrium of women with endometriosis via openalex

[22] Expression of the pluripotent transcription factor OCT4 promotes cell migration in endometriosis via openalex

[23] Fractalkine/CX3CR1 Contributes to Endometriosis-Induced Neuropathic Pain and Mechanical Hypersensitivity in Rats via openalex

[24] Fractalkine in the peritoneal fluid of women with endometriosis via openalex

[25] Fractalkine/<scp>CX</scp>3<scp>CR</scp>1 is involved in the pathogenesis of endometriosis by regulating endometrial stromal cell proliferation and invasion via openalex

[26] Functional changes of immune cells: signal of immune tolerance of the ectopic lesions in endometriosis? via openalex

[27] G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils via openalex

[28] Genomic Function of Estrogen Receptor β in Endometriosis via openalex

[29] Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis via openalex

[30] IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORγt/Blimp-1 signal to promote the progression of endometriosis via openalex

[31] IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis via openalex

[32] Immune-inflammation gene signatures in endometriosis patients via openalex

[33] Immunology of endometriosis via openalex

[34] Increased Expression of YAP Inhibited the Autophagy Level by Upregulating mTOR Signal in the Eutopic ESCs of Endometriosis via openalex

[35] Increased IL-25 levels in the peritoneal fluid of patients with endometriosis via openalex

[36] Inflammation and endometriosis via openalex

[37] Interleukin-12 but not interleukin-18 is associated with severe endometriosis via openalex

[38] Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis via openalex

[39] Interleukin‐9 produced by helper T cells stimulates interleukin‐8 expression in endometriosis via openalex

[40] Intracellular Wnt/Beta-Catenin Signaling Underlying 17beta-Estradiol-Induced Matrix Metalloproteinase 9 Expression in Human Endometriosis1 via openalex

[41] Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis via openalex

[42] Involvement of the Wnt/β-Catenin Signaling Pathway in the Cellular and Molecular Mechanisms of Fibrosis in Endometriosis via openalex

[43] Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis via openalex

[44] Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPk Activation in Endometriosis via openalex

[45] Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10 via openalex

[46] Metformin as a Potential Treatment Option for Endometriosis via openalex

[47] MiR-182 inhibits proliferation, migration, invasion and inflammation of endometrial stromal cells through deactivation of NF-κB signaling pathway in endometriosis via openalex

[48] Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model via openalex

[49] Notch activity mediates oestrogen-induced stromal cell invasion in endometriosis via openalex

[50] Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway via openalex

[51] P2X3 receptor involvement in endometriosis pain via ERK signaling pathway via openalex

[52] Pathogenesis and pathophysiology of endometriosis via openalex

[53] Pentoxifylline for the treatment of endometriosis-associated pain and infertility via openalex

[54] Peritoneal fluid concentrations of β-chemokines in endometriosis via openalex

[55] Peritoneal Fluid from Patients with Ovarian Endometriosis Displays Immunosuppressive Potential and Stimulates Th2 Response via openalex

[56] Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis via openalex

[57] Pro-inflammatory Cytokines (IL6, IL8 and TNF-a) in the Evaluation of Ovarian Endometriosis Cyst via openalex

[58] Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis via openalex

[59] Protein kinase inhibitors can control the progression of endometriosis <i>in vitro</i> and <i>in vivo</i> via openalex

[60] Proteome-Wide Effect of 17-β-Estradiol and Lipoxin A4 in an Endometriotic Epithelial Cell Line via openalex

[61] Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells via openalex

[62] Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis via openalex

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[64] Retinoic acid has the potential to suppress endometriosis development via openalex

[65] RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis via openalex

[66] Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis via openalex

[67] Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis via openalex

[68] TGF-βI Regulates Cell Migration through Pluripotent Transcription Factor OCT4 in Endometriosis via openalex

[69] Th1 and Th2 immune responses related to pelvic endometriosis via openalex

[70] The Anti‐Inflammatory Impact of Omega‐3 Polyunsaturated Fatty Acids During the Establishment of Endometriosis‐Like Lesions via openalex

[71] The Content of Cytokines IL-6, IL-8, TNF-α, IL-4 and the Level of CD86 and CD163 Expression in Peritoneal Fluid Macrophages Has a Reverse Correlation with the Degree of Severity of External Genital Endometriosis via openalex

[72] The Delicate Balance between the Good and the Bad IL-1 Proinflammatory Effects in Endometriosis via openalex

[73] The high level of RANTES in the ectopic milieu recruits macrophages and induces their tolerance in progression of endometriosis via openalex

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[75] T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal/mild endometriosis via openalex

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[78] The WNT/β-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway via openalex

[79] Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression via openalex

[80] Transcription factor 21 regulates expression of ERβ and SF-1 via upstream stimulatory factor-2 in endometriotic tissues via openalex

[81] Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist via openalex

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[83] Upregulation of Interleukin 35 in Patients With Endometriosis Stimulates Cell Proliferation via openalex

[84] Use of dopamine agonists to target angiogenesis in women with endometriosis via openalex

[85] USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway via openalex

[86] Valproic Acid and Progestin Inhibit Lesion Growth and Reduce Hyperalgesia in Experimentally Induced Endometriosis in Rats via openalex

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