Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis

Martin Sillem, M Sillem, S Prifti, M Neher, B Runnebaum
Human reproduction update · 1998 · vol. 4(5) , pp. 730–735 · doi:10.1093/humupd/4.5.730 · PMID:10027627 · W2152289540
article OA: bronze CC0 ⤵ 74 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometrial cell cultures from women with endometriosis showed increased soluble urokinase receptor secretion and upregulated TIMP-2 mRNA transcription, suggesting altered extracellular matrix turnover and increased invasive potential.

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Abstract

Essential features of endometrial physiology involve the extracellular matrix (ECM). In the pathogenesis of endometriosis, interactions of endometriosis cells with ECM can be postulated. Two systems of secreted proteases in the endometrium, the plasmin(ogen) activator/inhibitor and the matrix metalloproteinases and their inhibitors were examined in cell cultures of uterine endometrial cells from women with and without endometriosis. Soluble urokinase receptor secretion is increased, and mRNA transcription of tissue inhibitor of metalloproteinases-2 (TIMP-2) is upregulated by progestin in endometriosis. These findings are compatible with an altered ECM turnover in the endometrium of these patients that may explain a higher invasive potential of retrogradely menstruated endometrial fragments.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Endopeptidases Extracellular Matrix Gene Expression Regulation Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endopeptidases Endopeptidases Extracellular Matrix Extracellular Matrix Female Humans Plasminogen Activator Inhibitor 1

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References (27)

Cited by (50)

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