Endometriosis

Serdar E Bulun
The New England journal of medicine · 2009 · vol. 360(3) , pp. 268–279 · doi:10.1056/nejmra0804690 · PMID:19144942 · W4231488642
review OA: closed CC0 ⤵ 1389 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review highlights the roles of estrogen and inflammation, driven by a feedback cycle involving prostaglandins and aromatase, in the development and persistence of endometriotic tissue.

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Abstract

This review emphasizes the participation of estrogen and inflammation in the development of endometriosis. A feedback cycle in which prostaglandins and aromatase activity are prominent allows for the persistence of endometriotic tissue. Knowledge of this cycle has important implications for the treatment of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Estrogens Prostaglandins DNA Methylation Endometriosis Endometriosis Endometrium Endometrium Epigenesis, Genetic Estrogens Female Gene Expression Profiling Humans Infertility, Female Infertility, Female Ovarian Diseases Ovarian Diseases Peritoneal Diseases Peritoneal Diseases Prostaglandins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (90)

Cited by (50)

Source provenance

europepmc
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License: CC0 · commercial use OK