The relationship between 1,25(OH) 2 D 3 levels and interleukin-32 and vascular endothelial growth factor levels in endometriosis cyst tissue: An original article

Mirza Ismail, Hanom Husni Syam, Mulyanusa Amarullah Ritonga, Anita Rachmawati, Wiryawan Permadi, Ruswana Anwar, Shofwal Widad
SAGE open medicine · 2025 · vol. 13 , pp. 20503121251332405 · doi:10.1177/20503121251332405 · PMID:40291150 · W4409386966
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Abstract

Background: Endometriosis involves the presence of endometrial-like tissue outside the uterus, driven by inflammatory pathways including elevated interleukin-32 and vascular endothelial growth factor. One potential anti-inflammatory agent is active vitamin D (1,25(OH) 2 D 3 ). Objectives: This research investigates the correlation among 1,25(OH) 2 D 3 levels, interleukin-32, and vascular endothelial growth factor in confirmed endometriosis cases. Methods: This observational analytic correlational study aimed to explore the relationship between these inflammatory factors and vitamin D levels in endometriosis. The study involved 46 participants, with histopathologically confirmed endometriosis cyst tissue collected from patients undergoing laparotomy or laparoscopy at three hospitals: Dr. Hasan Sadikin Hospital Bandung, Cibabat General Hospital Cimahi, and Limijati Maternity and Children’s Hospital. The levels of interleukin-32, vascular endothelial growth factor, and 1,25(OH) 2 D 3 were measured using the enzyme-linked immunosorbent assay method at the Clinical Pathology Laboratory of Dr. Hasan Sadikin Hospital Bandung. Results: The study revealed significant negative correlations between 1,25(OH) 2 D 3 and both interleukin-32 ( r = −0.346; p = 0.019) and vascular endothelial growth factor levels ( r = −0.316; p = 0.032). Conversely, there was a significant positive correlation between vascular endothelial growth factor and interleukin-32 ( r = 0.490; p = 0.001). Conclusions: These findings underscore the role of active vitamin D in mitigating inflammation associated with endometriosis by reducing interleukin-32 and vascular endothelial growth factor, critical factors in inflammatory responses and blood vessel formation. Moreover, the positive association between vascular endothelial growth factor and interleukin-32 highlights their collaborative role in the inflammatory processes underlying endometriosis. This study contributes to understanding how vitamin D may modulate key inflammatory pathways implicated in the pathogenesis of this condition.

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endometriosis

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