The link between exposure to dioxin and endometriosis: a critical reappraisal of primate data

Guo SW, Sun-Wei Guo, Sun‐Wei Guo
Gynecologic and obstetric investigation · 2004 · vol. 57(3) , pp. 157–173 · doi:10.1159/000076374 · PMID:14739528 · W2053174345
Review OA: closed CC0 ⤵ 48 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper critically reappraises primate and human data, concluding that while dioxin may facilitate short-term endometrial implant survival in primates, there's no solid evidence linking dioxin exposure to the development of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a common and enigmatic disease affecting women of reproductive age. In 1993, Dr. Sherry Rier and her colleagues reported a serendipitous finding that quickly sent a shock wave through the endometriosis research community. They found that rhesus monkeys exposed daily for 4 years to dioxin developed endometriosis, with incidence and severity related to dose. The study prompted more animal and epidemiologic studies regarding the link between dioxin exposure and endometriosis. Yet, 10 years after the first piece of evidence was reported, the primate data are still equivocal, and the human data supporting the dioxin-endometriosis association are scanty and conflicting. While many reviewers of the subject recognize the need for more data, other reviewers tend to discount negative studies when reviewing positive studies. In this paper, a critical reappraisal of all evidence from human and primate data is presented. While there is evidence suggesting that exposure to dioxin may facilitate the short-term survival of endometrial implants in non-human primates, this evidence is not supported by both human and non-human primate studies evaluating the relationship between dioxin exposure and the development of spontaneous endometriosis. Weighing all converging evidence, it seems that there are no solid, credible data available at this moment to support the hypothesis that dioxin exposure may lead to the development of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Dioxins Endometriosis Animals Animals Dioxins Dioxins Disease Models, Animal Disease Models, Animal Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Endometriosis Endometriosis Environmental Exposure Environmental Exposure Female Female Humans Humans Macaca mulatta Macaca mulatta

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (94)

Cited by (48)

Source provenance

europepmc
last seen: 2026-11-13T07:00:47.251693+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:02:19.201584+00:00
unpaywall
last seen: 2026-11-13T07:27:04.437940+00:00
License: CC0 · commercial use OK