Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium

Maneesh N. Singh, Stringfellow HF, Helen F. Stringfellow, Siân E Taylor, Shelley E. Taylor, Taylor SE, Kate Ashton, Kate M Ashton, Ashton KM, Mushfika Ahmad, Muhammad Jamil Ahmad, Ahmad M, Abdo KR, Khalil Abdo, Khalil R Abdo, Omar M A El-Agnaf, Omar M. A. El‐Agnaf, Pierre L. Martin‐Hirsch, Pierre L Martin-Hirsch, Francis L. Martin, Martin FL, Francis Martin
Molecular human reproduction · 2008 · vol. 14(11) , pp. 655–663 · doi:10.1093/molehr/gan056 · PMID:18849443 · W2144863911
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This study found elevated intra-individual expression of CYP1A1 and gamma-SYNUCLEIN in ectopic ovarian endometriosis compared to eutopic endometrium.

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Abstract

Endometriosis is a debilitating disease in which apoptotic, genetic, immunological, angiogenic and environmental factors have been implicated. Endocrine-disrupting agents (e.g. dioxins) might be involved. Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1. Elevated expression of gamma-SYNUCLEIN (gamma-SYN) has been associated with hormone-related conditions. Tissue sets consisting of eutopic and ectopic (ovarian) endometrium from patients with stage 3 or 4 endometriosis were obtained. Following RNA extraction and reverse transcription, quantitative real-time reverse transcriptase-polymerase chain reaction was performed for anti-apoptotic B-cell leukaemia/lymphoma 2 (BCL-2), CYP1A1, CYP1B1, estrogen receptor (ER)alpha, ER beta and gamma-SYN. Immunohistochemical analyses for gamma-syn, ER alpha, ER beta and CYP1A1 were also conducted. A 3-9-fold increase in intra-individual expression of CYP1A1 in ectopic (ovarian) endometrium compared with eutopic tissue was observed; immunohistochemical analyses pointed to CYP1A1 being localized to the glandular epithelium. This intra-individual expression profile was not observed for CYP1B1 or BCL-2. However, a 5-53-fold intra-individual increase in gamma-SYN expression was also demonstrated in six of nine tissue sets (a further two showed an increase that was not considered significant) when comparing ectopic to eutopic endometrium; gamma-syn positivity was associated with endothelial cells. An elevation in ER beta was also noted when comparing ectopic to eutopic endometrium; with regard to ER alpha, this was inconsistent. These results suggest an up-regulation of dioxin-inducible CYP1A1 and gamma-SYN occurs in endometriosis. Whether gamma-syn may be a novel diagnostic marker for endometriosis remains to be ascertained.

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Condition tags

endometriosis

MeSH descriptors

Cytochrome P-450 CYP1A1 Endometriosis Endometrium gamma-Synuclein Gene Expression Regulation Adult Adult Aryl Hydrocarbon Hydroxylases Aryl Hydrocarbon Hydroxylases Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1B1 Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System Cytochrome P-450 Enzyme System Cytochrome P-450 Enzyme System Cytochrome P-450 Enzyme System Endometriosis Endometriosis

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