Endométriose et génétique : les gènes sont-ils responsables de la maladie ?

B Borghese; Bruno Borghese; D Vaiman; Daniel Vaiman; D de Ziegler; Dominique de Ziegler; C Chapron; Charles Chapron

doi:10.1016/j.jgyn.2010.03.006

Endométriose et génétique : les gènes sont-ils responsables de la maladie ?

B Borghese, Bruno Borghese, D Vaiman, Daniel Vaiman, D de Ziegler, Dominique de Ziegler, C Chapron, Charles Chapron

Journal de gynecologie, obstetrique et biologie de la reproduction · 2010 · vol. 39(3) , pp. 196–207 · doi:10.1016/j.jgyn.2010.03.006 · PMID:20399038 · W2083134073

review OA: closed CC0 ⤵ 14 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the genetic underpinnings of endometriosis, investigating the potential role of genes in the development of the disease.

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Condition tags

mesh:D004715

MeSH descriptors

Endometriosis Drug Resistance Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estrogens Estrogens Female Genetic Predisposition to Disease Homeodomain Proteins Homeodomain Proteins Humans Inflammation Polymorphism, Genetic Progesterone Receptors, Estrogen Receptors, Estrogen Receptors, Progesterone

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References (100)

Aberrant integrin expression in the endometrium of women with endometriosis via openalex
Aberrant integrin expression in the endometrium of women with endometriosis. via openalex
Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification via openalex
Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosis via openalex
Association between polymorphisms in the progesterone receptor gene and endometriosis via openalex
Association of Endometriosis Risk and Genetic Polymorphisms Involving Sex Steroid Biosynthesis and Their Receptors: A Meta-Analysis via openalex
Association of endometriosis with body size and figure via openalex
Comparison of c-DNA microarray analysis of gene expression between eutopic endometrium and ectopic endometrium (endometriosis) via openalex
Deeply infiltrating endometriosis affecting the rectum and lymph nodes via openalex
Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis via openalex
Dioxin pollution and endometriosis in Belgium via openalex
Dioxins and endometriosis: a plausible hypothesis. via openalex
Disrupted Cell Cycle Control in Cultured Endometrial Cells from Patients with Endometriosis Harboring the Progesterone Receptor Polymorphism PROGINS via openalex
DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection via openalex
Does endometriosis really have premalignant potential? A clonal analysis of laser‐microdissected tissue via openalex
Economic burden of endometriosis via openalex
EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis via openalex
Endometriosis via openalex
Endometriosis and Genetic Polymorphisms via openalex
Endometriosis and the neoplastic process via openalex
Endometriosis: cost estimates and methodological perspective via openalex
Endometriosis in monozygotic twins via openalex
Endometriosis in monozygotic twins via openalex
EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex
Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. via openalex
Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex
Familial endometriosis via openalex
Familial risk among Japanese patients with endometriosis via openalex
Familial Risk Among Patients with Endometriosis via openalex
Family trait analysis: A case-control study of 43 women with endometriosis and their best friends via openalex
Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis via openalex
Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis via openalex
Genetic influences on endometriosis in an Australian twin sample via openalex
Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression via openalex
Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. via openalex
Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 via openalex
Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential via openalex
Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis via openalex
Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studies via openalex
Gynecologic diseases get their genes via openalex
Heritable aspects of endometriosis via openalex
Histological classification of endometriosis as a predictor of response to treatment via openalex
Histopathological extent of rectal invasion by rectovaginal endometriosis via openalex
Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors via openalex
Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis via openalex
Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex
Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis via openalex
Mechanisms of excessive estrogen formation in endometriosis via openalex
Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis via openalex
Ovarian and extraovarian endometriosis-associated cancer via openalex
Pathogenic mechanisms in endometriosis-associated infertility via openalex
Pathology of endometriosis. via openalex
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex
Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex
Reactive Oxygen Species Controls Endometriosis Progression via openalex
Relationship between endometriosis and ovarian cancer. via openalex
Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system via openalex
Research Resource: Gene Expression Profile for Ectopic Versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential via openalex
Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay via openalex
Retrograde menstruation in healthy women and in patients with endometriosis. via openalex
Role of Endometriosis in Cancer and Tumor Development via openalex
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer via openalex
Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. via openalex
Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis via openalex
Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13–15 via openalex
Smoking habits of 411 women with histologically proven endometriosis and 567 unaffected women via openalex
Steroidogenic Factor-1 Expression in Ovarian Endometriosis via openalex
Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element via openalex
Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element via openalex
Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions via openalex
The endometriosis–ovarian cancer connection: the case against preventive surgery via openalex
The epidemiology of endometriosis via openalex
The Familial Occurrence of Endometriosis via openalex
The histogenesis of endometriosis via openalex
The histogenesis of endometriosis; recent contributions. via openalex
The Link between Exposure to Dioxin and Endometriosis: A Critical Reappraisal of Primate Data via openalex
The Pains of Endometriosis via openalex
The pathophysiology of endometriosis and adenomyosis: tissue injury and repair via openalex
The prevalence of endometriosis among African-American and African-indigenous women. via openalex
The relationship of endometriosis and ovarian malignancy: a review via openalex
The search for genes contributing to endometriosis risk via openalex
Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women via openalex
Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium via openalex
What makes a good case–control study? via openalex
Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium via openalex
W1985849948 via openalex
W2137282066 via openalex
W2137460866 via openalex
W1980694931 via openalex
W1976660314 via openalex
W2151078621 via openalex
W2154438286 via openalex
W2154794447 via openalex
W2157162135 via openalex
W2158342178 via openalex
W2160498502 via openalex
W2161688011 via openalex
W2164385268 via openalex
W1972563403 via openalex

Cited by (14)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:17:12.951333+00:00

License: CC0 · commercial use OK

[1] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[2] Aberrant integrin expression in the endometrium of women with endometriosis. via openalex

[3] Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification via openalex

[4] Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosis via openalex

[5] Association between polymorphisms in the progesterone receptor gene and endometriosis via openalex

[6] Association of Endometriosis Risk and Genetic Polymorphisms Involving Sex Steroid Biosynthesis and Their Receptors: A Meta-Analysis via openalex

[7] Association of endometriosis with body size and figure via openalex

[8] Comparison of c-DNA microarray analysis of gene expression between eutopic endometrium and ectopic endometrium (endometriosis) via openalex

[9] Deeply infiltrating endometriosis affecting the rectum and lymph nodes via openalex

[10] Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis via openalex

[11] Dioxin pollution and endometriosis in Belgium via openalex

[12] Dioxins and endometriosis: a plausible hypothesis. via openalex

[13] Disrupted Cell Cycle Control in Cultured Endometrial Cells from Patients with Endometriosis Harboring the Progesterone Receptor Polymorphism PROGINS via openalex

[14] DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection via openalex

[15] Does endometriosis really have premalignant potential? A clonal analysis of laser‐microdissected tissue via openalex

[16] Economic burden of endometriosis via openalex

[17] EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis via openalex

[18] Endometriosis via openalex

[19] Endometriosis and Genetic Polymorphisms via openalex

[20] Endometriosis and the neoplastic process via openalex

[21] Endometriosis: cost estimates and methodological perspective via openalex

[22] Endometriosis in monozygotic twins via openalex

[23] Endometriosis in monozygotic twins via openalex

[24] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[25] Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. via openalex

[26] Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex

[27] Familial endometriosis via openalex

[28] Familial risk among Japanese patients with endometriosis via openalex

[29] Familial Risk Among Patients with Endometriosis via openalex

[30] Family trait analysis: A case-control study of 43 women with endometriosis and their best friends via openalex

[31] Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis via openalex

[32] Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis via openalex

[33] Genetic influences on endometriosis in an Australian twin sample via openalex

[34] Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression via openalex

[35] Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. via openalex

[36] Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 via openalex

[37] Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential via openalex

[38] Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis via openalex

[39] Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studies via openalex

[40] Gynecologic diseases get their genes via openalex

[41] Heritable aspects of endometriosis via openalex

[42] Histological classification of endometriosis as a predictor of response to treatment via openalex

[43] Histopathological extent of rectal invasion by rectovaginal endometriosis via openalex

[44] Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors via openalex

[45] Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis via openalex

[46] Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex

[47] Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis via openalex

[48] Mechanisms of excessive estrogen formation in endometriosis via openalex

[49] Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis via openalex

[50] Ovarian and extraovarian endometriosis-associated cancer via openalex

[51] Pathogenic mechanisms in endometriosis-associated infertility via openalex

[52] Pathology of endometriosis. via openalex

[53] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[54] Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex

[55] Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex

[56] Reactive Oxygen Species Controls Endometriosis Progression via openalex

[57] Relationship between endometriosis and ovarian cancer. via openalex

[58] Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system via openalex

[59] Research Resource: Gene Expression Profile for Ectopic Versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential via openalex

[60] Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay via openalex

[61] Retrograde menstruation in healthy women and in patients with endometriosis. via openalex

[62] Role of Endometriosis in Cancer and Tumor Development via openalex

[63] Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer via openalex

[64] Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. via openalex

[65] Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis via openalex

[66] Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13–15 via openalex

[67] Smoking habits of 411 women with histologically proven endometriosis and 567 unaffected women via openalex

[68] Steroidogenic Factor-1 Expression in Ovarian Endometriosis via openalex

[69] Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element via openalex

[70] Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element via openalex

[71] Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions via openalex

[72] The endometriosis–ovarian cancer connection: the case against preventive surgery via openalex

[73] The epidemiology of endometriosis via openalex

[74] The Familial Occurrence of Endometriosis via openalex

[75] The histogenesis of endometriosis via openalex

[76] The histogenesis of endometriosis; recent contributions. via openalex

[77] The Link between Exposure to Dioxin and Endometriosis: A Critical Reappraisal of Primate Data via openalex

[78] The Pains of Endometriosis via openalex

[79] The pathophysiology of endometriosis and adenomyosis: tissue injury and repair via openalex

[80] The prevalence of endometriosis among African-American and African-indigenous women. via openalex

[81] The relationship of endometriosis and ovarian malignancy: a review via openalex

[82] The search for genes contributing to endometriosis risk via openalex

[83] Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women via openalex

[84] Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium via openalex

[85] What makes a good case–control study? via openalex

[86] Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium via openalex

[87] W1985849948 via openalex

[88] W2137282066 via openalex

[89] W2137460866 via openalex

[90] W1980694931 via openalex

[91] W1976660314 via openalex

[92] W2151078621 via openalex

[93] W2154438286 via openalex

[94] W2154794447 via openalex

[95] W2157162135 via openalex

[96] W2158342178 via openalex

[97] W2160498502 via openalex

[98] W2161688011 via openalex

[99] W2164385268 via openalex

[100] W1972563403 via openalex