The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta‐analysis

H M Harb, HM Harb, I D Gallos, Ioannis Gallos, Justin Chu, J Chu, M Harb, M.D. DINA Y. MANSOUR HISHAM HARB, A Coomarasamy
BJOG: An International Journal of Obstetrics & Gynaecology · 2013 · vol. 120(11) , pp. 1308–1320 · doi:10.1111/1471-0528.12366 · PMID:23834505 · W2107160113
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This systematic review and meta-analysis of 27 studies found that severe endometriosis (stage III/IV) is associated with reduced implantation and clinical pregnancy rates in women undergoing IVF.

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Abstract

BACKGROUND: Endometriosis is found in 0.5-5% of fertile women and 25-40% of infertile women. It is known that endometriosis is associated with infertility, but there is uncertainty whether women with endometriosis have adverse pregnancy outcomes in in vitro fertilisation (IVF) treatment. OBJECTIVES: To explore the association between endometriosis and IVF outcome. SEARCH STRATEGY: Searches were conducted on MEDLINE, EMBASE, Cochrane Library and Web of Science (inception, December 2012) in all languages, together with reference lists of retrieved papers. SELECTION CRITERIA: Studies comparing IVF outcome in women with endometriosis with women without endometriosis. Patients were classified by stage of endometriosis. The outcomes were fertilisation, implantation, clinical pregnancy and live birth rates. Study selection was conducted independently by two reviewers. The Newcastle-Ottawa Quality Assessment Scale was used for quality assessment. DATA COLLECTION AND ANALYSIS: Data extraction was conducted independently by two reviewers. Relative risks from individual studies were meta-analysed. MAIN RESULTS: Twenty-seven observational studies were included, comprising 8984 women. Meta-analysis of these studies showed that fertilisation rates were reduced in stage I/II of endometriosis (relative risk [RR] = 0.93, 95% confidence interval [95% CI] 0.87-0.99, P = 0.03). There was a decrease in the implantation rate (RR = 0.79, 95% CI 0.67-0.93, P = 0.006) and clinical pregnancy rate (RR = 0.79, 95% CI 0.69-0.91, P = 0.0008) in women with stage III/IV endometriosis undergoing IVF treatment. CONCLUSION: The presence of severe endometriosis (stage III/IV) is associated with poor implantation and clinical pregnancy rates in women undergoing IVF treatment.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Uterine Diseases Embryo Implantation Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Live Birth Pregnancy Pregnancy Rate Severity of Illness Index Uterine Diseases Uterine Diseases

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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