The effect of endometriomas on in vitro fertilization outcome

Alexander M. Dlugi, A M Dlugi, R A Loy, Randall A. Loy, S Dieterle, Stefan Dieterle, Steven R Bayer, S R Bayer, M M Seibel, Markus J. Seibel, Machelle M. Seibel
Journal of in vitro fertilization and embryo transfer : IVF · 1989 · vol. 6(6) , pp. 338–341 · doi:10.1007/bf01138773 · PMID:2517506 · W2004377494
article OA: closed CC0 ⤵ 26 in-corpus citations
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Patients with ovarian endometriomas had fewer follicles and fertilization cycles, and no pregnancies, compared to those with hydrosalpinges, indicating endometriomas adversely affect IVF outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This study compared IVF outcomes in two small groups of patients with similar severe pelvic adhesions: seven patients with ovarian endometriomas (12 total stimulation cycles) versus eight patients with hydrosalpinges (27 cycles). The groups did not differ in days to stimulation or peak serum estradiol, but the endometrioma group had significantly fewer preovulatory follicles (1.42 vs 3.33), fewer cycles with fertilization (28% vs 84%), and fewer embryos transferred (0.78 vs 2.56); pregnancies occurred only in the hydrosalpinges group (three total) with none in the endometrioma group. A key limitation is the very small sample size and the retrospective-like, nonrandomized comparison across groups with different underlying tubal pathology. This paper is centrally about endometriosis — it evaluates how ovarian endometriomas affect IVF fertilization and pregnancy outcomes.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 3,621 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

To determine the effect of ovarian endometriomas on in vitro fertilization (IVF) outcome, two groups of patients were studied. Group I consisted of seven patients with ovarian endometriomas and severe pelvic adhesions treated for a total of 12 cycles. Group II patients consisted of eight patients with hydrosalpinges and comparable pelvic adhesions treated for a total of 27 cycles. There were no differences in the number of days required for stimulation or in the serum estradiol levels attained between the two groups. Group I patients were noted to have significantly fewer preovulatory follicles (1.42 vs 3.33,P<0.005), cycles with fertilization (28 vs 84%,P<0.005), and embryos transferred (0.78 vs 2.56,P=0.01) than Group II patients. Three pregnancies occurred in Group II, while there were no conceptions among Group I patients. This study suggests that the presence of an ovarian endometrioma(s) has an adverse effect on IVF outcome and suggests that patients with ovarian endometriomas should have them removed prior to undergoing IVF. Similar content being viewed by others

References

Chillik CF, Acosta AA, Garcia JE, Perers S, Van Uem JFHM, Rosenwaks Z, Jones HW Jr: The role of in vitro fertilization in infertile patients with endometriosis. Fertil Steril 1985;44:56–61 Matson PL, Yovich JL: The treatment of infertility associated with endometriosis by in vitro fertilization. Fertil Steril 1986;46:432–434 Yovich JL, Matson PL, Richardson PA, Hilliard C: Hormonal profiles and embryo quality in women with severe endometriosis treated by in vitro fertilization embryo transfer. Fertil Steril 1988;50:308–313 Taymor ML, Seibel MM, Oskowitz SP, Smith DM, Lee G: In vitro fertilization and embryo transfer: An individualized approach to ovulation induction. J Vitro Fert Embryo Transfer 1985;2:162–165 Walmer DK, Haney AF: Subfertility associated with endometriosis: Potential influences of the peritoneal environment. Semin Reprod Endcrinol 1988;6:263–267 Mahadevan MM, Wiseman D, Leader A, Taylor PJ: The effects of ovarian adhesive disease upon follicular deveiopment in cycles of controlled stimulation for in vitro fertilization. Fertil Sterii 1985;44:489–492 Diamond MP, Pellicer A, Boyers SP, DeChemey AH: The effect of periovarian adhesions on follicular development in patients undergoing stimulation for in vitro fertilizationembryo transfer. Fertil Steril 1988;499:100–103 Vercellini P, Fedele L, Dorta M, Brioschi D, Bianchi S: Endometriosis and ovulation: Ultrasound and hormone study. Forty-fourth Annual Meeting of the American Fertility Society, Atlanta, Georgia, Oct 10–13, 1988 (abstr) Wardle PG, McLaughlin EA, McDermott A, Mitchell JD, Ray BD, Hull MGR: Endometriosis and ovulatory disorder: reduced fertilization in vitro compared with tubal and unexplained infertility. Lancet 1985;2:236–237 Mahadevan MM, Trounson AO, Leeton JF: The relationship of tubal blockage, infertility of unknown cause, suspected male infertility, and endometriosis to success of in vitro fertilization and embryo transfer. Fertil Steril 1983;40:755–762 Mao KR, Haines CJ, Tam PPL: Successful oocyte retrieval and in vitro fertilization following ultrasound-directed aspiration of endometriomas. J Vitro Fert Embryo Transfer 1986;3:333–337 Author information Authors and Affiliations Rights and permissions About this article Cite this article Dlugi, A.M., Loy, R.A., Dieterle, S. et al. The effect of endometriomas on in vitro fertilization outcome. J Assist Reprod Genet 6, 338–341 (1989). https://doi.org/10.1007/BF01138773 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF01138773

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

mesh:D004715

MeSH descriptors

Endometriosis Fertilization Fertilization in Vitro Ovarian Neoplasms Adult Embryo Transfer Endometriosis Estradiol Estradiol Female Fertilization Humans Luteinizing Hormone Luteinizing Hormone Menotropins Menotropins Ovarian Neoplasms Ovulation Ovulation Pelvic Inflammatory Disease

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (26)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:09:10.744835+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK