Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread

Antoine Naem; Harald Krentel; Gaby Moawad; Joelle Naem; Renato Venezia; Andrea Etrusco; Sanja Terzic; Antonio Simone Laganà

doi:10.1016/j.bpobgyn.2024.102500

Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread

Antoine Naem, Harald Krentel, Gaby Moawad, Joelle Naem, Renato Venezia, Andrea Etrusco, Sanja Terzic, Antonio Simone Laganà

Best practice & research. Clinical obstetrics & gynaecology · 2024 · vol. 95 , pp. 102500 · doi:10.1016/j.bpobgyn.2024.102500 · PMID:38772765 · W4396721810

article OA: closed CC0 ⤵ 3 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper navigates the complex landscape of hormonal therapies used prior to in vitro fertilization for women with endometriosis, seeking an optimal treatment pathway.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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[1] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[2] A comparison of two months pretreatment with GnRH agonists with or without an aromatase inhibitor in women with ultrasound-diagnosed ovarian endometriomas undergoing IVF via openalex

[3] A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis via openalex

[4] Aromatase and other steroidogenic genes in endometriosis: translational aspects via openalex

[5] Aromatase inhibitor (anastrozole) affects growth of endometrioma cells in culture via openalex

[6] Aromatase Inhibitors for Endometriosis-Associated Infertility; Do We Have Sufficient Evidence? via openalex

[7] Aromatase inhibitors in post-menopausal endometriosis via openalex

[8] Cancer-Associated Mutations in Endometriosis without Cancer via openalex

[9] Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside via openalex

[10] Controlled ovarian stimulation for endometriosis patients with ultra‐long <scp>GnRH</scp>‐agonist or <scp>GnRH</scp>‐antagonist protocols: A retrospective study by propensity score matching via openalex

[11] Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis via openalex

[12] Delayed diagnosis of endometriosis disadvantages women in ART: a retrospective population linked data study via openalex

[13] Dienogest via openalex

[14] Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis via openalex

[15] Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex

[16] Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF via openalex

[17] Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles via openalex

[18] Direct proportional relationship between endometrioma size and ovarian parenchyma inadvertently removed during cystectomy, and its implication on the management of enlarged endometriomas via openalex

[19] Effect of endometriosis on in vitro fertilization via openalex

[20] Effect of GnRH agonist before IVF on outcomes in infertile endometriosis patients: a randomized controlled trial via openalex

[21] Effect of progestogen therapy on follicular development, related hormone concentrations and fertilization in vitro in unstimulated cycles and unexplained and endometriosis-associated infertility via openalex

[22] Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis via openalex

[23] Effects of Dienogest on Surgically Induced Endometriosis in Rats after Repeated Oral Administration via openalex

[24] Effects of endometriosis on in vitro fertilisation – Myth or reality? via openalex

[25] Efficacy of Different Progestins in Women With Advanced Endometriosis Undergoing Controlled Ovarian Hyperstimulation for in vitro Fertilization-A Single-Center Non-inferiority Randomized Controlled Trial via openalex

[26] Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis via openalex

[27] Endometriosis: a dysfunction and disease of the archimetra via openalex

[28] Endometriosis and Assisted Reproductive Technologies: Maximizing Outcomes via openalex

[29] Endometriosis and Infertility via openalex

[30] Endometriosis and Inflammation in Infertility via openalex

[31] Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis via openalex

[32] Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options via openalex

[33] Endometriosis-associated infertility treated by long-term gonadotropin-releasing hormone agonist administration and assisted fertilization via openalex

[34] Endometriosis does not impact live-birth rates in frozen embryo transfers of euploid blastocysts via openalex

[35] Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex

[36] Endometriosis: pathogenesis and treatment via openalex

[37] Evidence for Asymmetric Distribution of Sciatic Nerve Endometriosis via openalex

[38] Expression of Concern: Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis via openalex

[39] GnRH agonist administration prior to embryo transfer in freeze-all cycles of patients with endometriosis or aberrant endometrial integrin expression via openalex

[40] GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity via openalex

[41] Gonadotrophin-releasing hormone analogues for pain associated with endometriosis via openalex

[42] Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas via openalex

[43] GYNECOLOGY: Exposure of Human Oocytes to Endometrioma Fluid Does Not Alter Fertilization or Early Embryo Development via openalex

[44] Heritable aspects of endometriosis via openalex

[45] High-dose pilot study with the novel progestogen dienogestin patients with endometriosis via openalex

[46] High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome via openalex

[47] High rates of pregnancy after long-term down-regulation of women with severe endometriosis via openalex

[48] HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility via openalex

[49] Immunobiology of endometriosis via openalex

[50] Impact of adenomyosis and endometriosis on IVF/ICSI pregnancy outcome in patients undergoing gonadotropin-releasing hormone agonist treatment and frozen embryo transfer via openalex

[51] Impact of dienogest pretreatment on IVF-ET outcomes in patients with endometriosis: a systematic review and meta-analysis via openalex

[52] Impact of moderate-to-severe endometriosis on IVF cumulative live birth rate: a retrospective matched cohort study via openalex

[53] Impact of stage iii–iv endometriosis on recipients of sibling oocytes: matched case-control study via openalex

[54] Impact of Surgery for Deep Infiltrative Endometriosis before In Vitro Fertilization: A Systematic Review and Meta-analysis via openalex

[55] Impacts of medroxyprogesterone acetate on oocytes and embryos: matched case-control study in women with stage III–IV ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization via openalex

[56] Increased levels of oxidative stress markers in the peritoneal fluid of women with endometriosis via openalex

[57] Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis via openalex

[58] Interventions for women with endometrioma prior to ART via openalex

[59] Is aromatase expression in the endometrium the cause of endometriosis and related infertility? via openalex

[60] Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study via openalex

[61] Isolated infiltrative endometriosis of the sciatic nerve: a report of three patients via openalex

[62] Is the long‐acting gonadotropin‐releasing hormone agonist long protocol better for patients with endometriosis undergoing <scp>IVF</scp>? via openalex

[63] Laparoscopic Findings, Management, Histopathology, and Outcomes in 25 Women with Cyclic Leg Pain via openalex

[64] Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial via openalex

[65] Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis via openalex

[66] Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis via openalex

[67] Magnetic resonance imaging to assess familial risk in relatives of women with endometriosis via openalex

[68] Management of endometriomas in women requiring IVF: to touch or not to touch via openalex

[69] Management of recurrent implantation failure by gonadotropin-releasing hormone agonist and aromatase inhibitor suppression, in women without evidence of endometriosis via openalex

[70] Ovarian cortex surrounding benign neoplasms: A histologic study via openalex

[71] Pathogenesis of endometriosis: the genetic/epigenetic theory via openalex

[72] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[73] Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis via openalex

[74] Pre- and Post-Surgical Management of Endometriosis via openalex

[75] Pregnancy outcomes after controlled ovarian hyperstimulation in women with endometriosis-associated infertility: GnRH-agonist versus GnRH-antagonist via openalex

[76] Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome via openalex

[77] Pretreatment with dienogest in women with endometriosis undergoing IVF after a previous failed cycle via openalex

[78] Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex

[79] Progestin-Primed Ovarian Stimulation Protocol for Patients With Endometrioma via openalex

[80] Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells via openalex

[81] Protective effect of dienogest on chemotherapy-induced reduced fertility in female rats via openalex

[82] Puzzling Out the Genetic Architecture of Endometriosis: Whole-Exome Sequencing and Novel Candidate Gene Identification in a Deeply Clinically Characterised Cohort via openalex

[83] Rate of severe ovarian damage following surgery for endometriomas via openalex

[84] RCT to evaluate the influence of adjuvant medical treatment of peritoneal endometriosis on the outcome of IVF via openalex

[85] Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis via openalex

[86] Revised American Society for Reproductive Medicine classification of endometriosis: 1996 via openalex

[87] Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial via openalex

[88] Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality via openalex

[89] Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[90] Surgery Versus Pharmacological Treatment for Endometriosis via openalex

[91] The effectiveness of different down-regulating protocols on in vitro fertilization-embryo transfer in endometriosis: a meta-analysis via openalex

[92] The effect of endometriosis on <i>in vitro</i> fertilisation outcome: a systematic review and meta‐analysis via openalex

[93] The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial via openalex

[94] The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer via openalex

[95] Theories on the Pathogenesis of Endometriosis via openalex

[96] The Pathogenesis of Endometriosis: Are Endometrial Stem/Progenitor Cells Involved? via openalex

[97] The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex

[98] The presence of ovarian endometrioma adversely affect ovarian reserve and response to stimulation but not oocyte quality or IVF/ICSI outcomes: a retrospective cohort study via openalex

[99] The severity and frequency distribution of endometriosis subtypes at different ages: a model to understand the natural history of endometriosis based on single centre/single surgeon data via openalex

[100] The ultra-long study: a randomized controlled trial evaluating long-term GnRH downregulation prior to ART in women with endometriosis via openalex