Endometriosis and Infertility

Sebiha Ozkan, Sebiha Özkan, William Murk, Aydin Arici, Aydın Arıcı
Annals of the New York Academy of Sciences · 2008 · vol. 1127(1) , pp. 92–100 · doi:10.1196/annals.1434.007 · PMID:18443335 · W2109367793
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Endometriosis, a common cause of infertility, is managed surgically, with assisted reproductive technologies recommended based on disease stage and pelvic anatomy.

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Abstract

Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5-5% in fertile and 25-40% in infertile women. The optimal choice of management for endometriosis-associated infertility remains obscure. Removal or suppression of endometrial deposits by medical or surgical means constitutes the basis of endometriosis management. Current evidence indicates that suppressive medical treatment of endometriosis does not benefit fertility and should not be used for this indication alone. Surgery is probably efficacious for all stages of the disease. Controlled ovarian hyperstimulation with intrauterine insemination is recommended in early-stage and surgically corrected endometriosis when pelvic anatomy is normal. In advanced cases, in vitro fertilization is a treatment of choice, and its success may be augmented with prolonged gonadotropin-releasing hormone analog treatment. Further randomized clinical trials focusing on diverse etiopathogenic mechanisms and therapeutic innovation are necessary to find more conclusive, evidence-based answers regarding this enigmatic disease.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Infertility, Female Endometriosis Endometriosis Evidence-Based Medicine Female Fertilization in Vitro Humans Infertility Infertility, Female Infertility, Female Male Ovulation Induction Pregnancy Prevalence Reproductive Techniques, Assisted Treatment Outcome

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References (100)

Cited by (50)

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