Implantation defect in endometriosis: endometrium or peritoneal fluid.
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This review summarizes evidence for altered endometrial receptivity and peritoneal fluid environments contributing to implantation defects in women with endometriosis.
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Abstract
Clinical observations indicate that an implantation defect occurs in women with endometriosis. Despite intense research, the role of alterations in endometrial receptivity and the peritoneal fluid microenvironment in the derangement of implantation in endometriosis remains controversial. In this review, the evidence for the altered endometrial receptivity and peritoneal environment are summarized, and their effects on the implantation defect in women with endometriosis are discussed. Recent studies on cell adhesion molecules and their ligands, apoptosis, homeobox genes and the direct action of gonadotrophin-releasing hormone analogues are reviewed with respect to their contribution to endometrial receptivity in endometriosis. The possible mechanisms by which an altered peritoneal environment of endometriosis may affect implantation, including cytokine concentrations, iron metabolism, biochemical factors and embryotoxicity are discussed.
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Cited by (23)
- The Effect of Endometriosis on In Vitro Fertilization Outcomes: A Systematic Review and Meta-Analysis 2024
- Comparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation. 2019
- Perfil diferencial de microRNAs em células do Cummulus oophorus de mulheres inférteis com e sem endometriose submetidas à estimulação ovariana 2018
- Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis 2018
- Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis 2016
- Why Endometriosis Causes Infertility? 2016
- Potential New Drugs for Endometriosis: Experimental Evidence 2014
- The effect of endometriosis on <i>in vitro</i> fertilisation outcome: a systematic review and meta‐analysis 2013
- Etude phénotypique des cellules endométriosiques profondes 2012
- High prevalence of endometrial polyps in endometriosis-associated infertility 2011
- Pathophysiology of Infertility in Endometriosis 2011
- Laparoscopic Treatment of Acute Ovarian Incarceration into the Pelvic Peritoneal Sac 2009
- Involvement of resistance to apoptosis in the pathogenesis of endometriosis. 2009
- The impact of endometriosis, endometrioma and ovarian cystectomy on assisted reproductive technology 2009
- Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1 2008
- Decreased lactoferrin levels in peritoneal fluid of women with minimal endometriosis 2006
- Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates 2005
- Understanding endometriosis is the key to successful therapeutic management 2004
- Leptin is not involved in the pathophysiology of endometriosis-related infertility 2004
- Deficient Expression of Tumor Necrosis Factor Receptor Type 2 in the Endometrium of Women with Endometriosis 2003
- Oxidative stress and peritoneal endometriosis 2002
- New advances in the understanding of endometriosis related infertility 2002
- Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis 2002
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
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- pubmed
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