Serum Biomarker for Diagnosis of Endometriosis
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Abstract
Endometriosis is estimated to affect 10% of women during the reproductive years. The lack of a non-invasive diagnostic test significantly contributes to the long delay between onset of the symptoms and definitive diagnosis of endometriosis. This case-control study was conducted to identify specific endometriosis antigens using 2D gel analysis in women with endometriosis (n = 5) and without endometriosis (n = 5). Differentially expresses spots were analyzed using matrix-assisted laser desorption/ionization-time-of-flight/mass spectrometry (nanoLC-ESI-MS/MS) with MASCOT analysis, in order to identify the corresponding proteins. ELISAs were performed on a different cohort of endometriosis (n = 120) and healthy patients (n = 20) in order to confirm the differential expression of the identified proteins. ROC analysis of ELISA results confirmed the statistical significance of the differential expression for one of these proteins: Zn-alpha2-glycoprotein (P = 0.019). We propose the analysis of the expression level of this protein in the serum as a new non-invasive diagnostic test for endometriosis.
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Cited by (29)
- Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis 2024
- Prototype Salivary Assay for Quantification of Two Biomarkers for In Vitro Diagnosis of Endometriosis 2024
- Pathogenesis of Endometriosis: Focus on Adenogenesis-related Factors 2023
- Proteomics in the study of female fertility: an update 2023
- Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms 2022
- Elevated Circulatory Proline to Glutamine Ratio (PQR) in Endometriosis and Its Potential as a Diagnostic Biomarker 2022
- Endometriosis biomarkers of the disease: an update 2022
- New Insights in Pathogenesis of Endometriosis 2022
- Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors 2021
- Development of an impedimetric immunosensor for machine learning-based detection of endometriosis: A proof of concept 2021
- The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis 2021
- Endometriosis: A Retrospective Analysis on Diagnostic Data in a Cohort of 4,401 Patients 2021
- Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target 2021
- The Presence of Endometriosis in the Human Fetus 2020
- Complement Component 3 expressed by the endometrial ectopic tissue is involved in the endometriotic lesion formation through mast cell activation 2020
- Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives 2020
- Looking for an effective and non-invasive diagnostic test for endometriosis: where are we? 2018
- Endometriosis of female reproductive organs. Pathomorphology, diagnosis, treatment and prevention 2018
- Biomarkers for Diagnosis of Pre-Eclampsia and Endometriosis 2018
- Peripheral Blood Biomarkers for Endometriosis 2017
- Upregulation of Interleukin 35 in Patients With Endometriosis Stimulates Cell Proliferation 2017
- Novel dietary supplement association reduces symptoms in endometriosis patients 2017
- Clinical picture and diagnosis of genital endometriosis 2016
- Prototype of Multiplex Bead Assay for Quantification of Three Serum Biomarkers for In Vitro Diagnosis of Endometriosis 2016
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Endometriosis Biomarkers in Body Fluids 2016
- Elevated periostin in serum and peritoneal washing fluids as potential biomarkers for endometriosis 2016
- Update on Biomarkers for the Detection of Endometriosis 2015
- New evidence in endometriosis 2015
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:18:35.150238+00:00
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