Endometriosis biomarkers of the disease: an update

Diana Encalada Soto, Sarah Rassier, Isabel C Green, Tatnai Burnett, Tatnai L. Burnett, Zaraq Khan, Adela G. Cope, Adela Cope
Current opinion in obstetrics & gynecology · 2022 · vol. 34(4) , pp. 210–219 · doi:10.1097/gco.0000000000000798 · PMID:35895963 · W4288060860
review OA: closed CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Researchers reviewed potential noninvasive endometriosis biomarkers, finding promise in microRNAs, proteomics, metabolomics, genomics, and the microbiome for improving diagnosis.

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Abstract

PURPOSE OF REVIEW: Endometriosis is a complex benign gynaecologic condition with heterogenous presentations and a large impact on the global healthcare system and on the quality of life for millions of women. Currently, the gold standard for diagnosis involves direct visualization of lesions during surgery confirmed by histopathological diagnosis, resulting in an average delay in its initial diagnosis of 8-10 years. Therefore, the search for noninvasive diagnostic testing options has been subject to a large body of research. RECENT FINDINGS: Multiple potential biomarkers have been explored for noninvasive testing for endometriosis, including glycoproteins, inflammatory cytokines, immunological molecules, angiogenesis markers, hormones, micro RNAs (miRNAs), proteomics, metabolomics, genomics and the microbiome. SUMMARY: Although there are challenges to consider, areas for real promise and advancement in the noninvasive diagnosis of endometriosis are currently being explored with real promise in the area of miRNAs, proteomics, metabolomics, genomics and the microbiome.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Cited by (15)

Source provenance

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