Serum Biomarker for Diagnosis of Endometriosis
article
OA: closed
CC0
⤵ 29 in-corpus citations
Abstract
Endometriosis is estimated to affect 10% of women during the reproductive years. The lack of a non-invasive diagnostic test significantly contributes to the long delay between onset of the symptoms and definitive diagnosis of endometriosis. This case-control study was conducted to identify specific endometriosis antigens using 2D gel analysis in women with endometriosis (n = 5) and without endometriosis (n = 5). Differentially expresses spots were analyzed using matrix-assisted laser desorption/ionization-time-of-flight/mass spectrometry (nanoLC-ESI-MS/MS) with MASCOT analysis, in order to identify the corresponding proteins. ELISAs were performed on a different cohort of endometriosis (n = 120) and healthy patients (n = 20) in order to confirm the differential expression of the identified proteins. ROC analysis of ELISA results confirmed the statistical significance of the differential expression for one of these proteins: Zn-alpha2-glycoprotein (P = 0.019). We propose the analysis of the expression level of this protein in the serum as a new non-invasive diagnostic test for endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (22)
- Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK via openalex
- Embryologic origin of endometriosis: Analysis of 101 human female fetuses via openalex
- Endometriosis via openalex
- Endometriosis: Pathogenesis, diagnosis, therapy and association with cancer (Review) via openalex
- ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
- History of adenomyosis via openalex
- Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers via openalex
- Peripheral biomarkers of endometriosis: a systematic review via openalex
- Pre-natal exposure of mice to bisphenol A elicits an endometriosis-like phenotype in female offspring via openalex
- Proteomics Analysis of Plasma for Early Diagnosis of Endometriosis via openalex
- Rectovaginal septum endometriosis: an immunohistochemical analysis of 62 cases. via openalex
- Surgical procedures and their cost estimates among women with newly diagnosed endometriosis: a US database study via openalex
- Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects via openalex
- What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis via openalex
- Why We Need a Noninvasive Diagnostic Test for Minimal to Mild Endometriosis with a High Sensitivity via openalex
- W2132587402 via openalex
- W1977757908 via openalex
- W2165441271 via openalex
- W4211081176 via openalex
- W2038221637 via openalex
- W6678485308 via openalex
- W1992451410 via openalex
Cited by (29)
- Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis 2024
- Prototype Salivary Assay for Quantification of Two Biomarkers for In Vitro Diagnosis of Endometriosis 2024
- Pathogenesis of Endometriosis: Focus on Adenogenesis-related Factors 2023
- Proteomics in the study of female fertility: an update 2023
- Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms 2022
- Elevated Circulatory Proline to Glutamine Ratio (PQR) in Endometriosis and Its Potential as a Diagnostic Biomarker 2022
- Endometriosis biomarkers of the disease: an update 2022
- New Insights in Pathogenesis of Endometriosis 2022
- Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors 2021
- Development of an impedimetric immunosensor for machine learning-based detection of endometriosis: A proof of concept 2021
- The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis 2021
- Endometriosis: A Retrospective Analysis on Diagnostic Data in a Cohort of 4,401 Patients 2021
- Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target 2021
- The Presence of Endometriosis in the Human Fetus 2020
- Complement Component 3 expressed by the endometrial ectopic tissue is involved in the endometriotic lesion formation through mast cell activation 2020
- Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives 2020
- Looking for an effective and non-invasive diagnostic test for endometriosis: where are we? 2018
- Endometriosis of female reproductive organs. Pathomorphology, diagnosis, treatment and prevention 2018
- Biomarkers for Diagnosis of Pre-Eclampsia and Endometriosis 2018
- Peripheral Blood Biomarkers for Endometriosis 2017
- Upregulation of Interleukin 35 in Patients With Endometriosis Stimulates Cell Proliferation 2017
- Novel dietary supplement association reduces symptoms in endometriosis patients 2017
- Clinical picture and diagnosis of genital endometriosis 2016
- Prototype of Multiplex Bead Assay for Quantification of Three Serum Biomarkers for In Vitro Diagnosis of Endometriosis 2016
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Endometriosis Biomarkers in Body Fluids 2016
- Elevated periostin in serum and peritoneal washing fluids as potential biomarkers for endometriosis 2016
- Update on Biomarkers for the Detection of Endometriosis 2015
- New evidence in endometriosis 2015
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:18:35.150238+00:00
License: CC0
· commercial use OK