Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis

Jehn-Hsiahn Yang, Jehn‐Hsiahn Yang, Ming‐Yih Wu, Ming-Yih Wu, Chin-Der Chen, Chin‐Der Chen, Mei-Jou Chen, Mei‐Jou Chen, Yu-Shih Yang, Yu‐Shih Yang, Hong‐Nerng Ho, Hong-Nerng Ho
Human Reproduction · 2007 · vol. 22(4) , pp. 945–952 · doi:10.1093/humrep/del493 · PMID:17208943 · W2143564174
article OA: bronze CC0 ⤵ 30 in-corpus citations
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Endometrial stromal cells from women with adenomyosis showed reduced apoptosis and increased proliferation in vitro compared to controls.

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Abstract

BACKGROUND: The eutopic endometrium in a woman suffering from adenomyosis is known to be biologically different from that of healthy women. The aim of this study was to examine the apoptosis and proliferation of eutopic endometrium from women with adenomyosis. METHODS: We enrolled 23 women with adenomyosis (study group) and 21 without (control group). Eutopic endometrium was obtained and separated into single endometrial stromal cells (ESCs). ESCs were treated in vitro with hydrogen peroxide (H(2)O(2)) to examine their apoptosis using a fluorescence-activated cell sorter. Cells were also treated with estradiol (E(2)), medroxyprogesterone acetate, interleukin (IL)-6, lipopolysaccharide and interferon-gamma (IFN-gamma) to test their proliferation using a non-radioactive cell proliferation assay. RESULTS: The percentage of annexin V ( + )/7-amino-actinomycin D ( + ) ESCs was much lower in women with adenomyosis after 24 h culture with and without H(2)O(2) treatment when compared with the control group. ESCs of adenomyosis proliferated more rapidly than those of the control group, whether they were cultured alone or were treated with E(2), MPA, IL-6 or IFN-gamma. The immunocytochemical Ki-67 labelling index was much more prominent in adenomyotic ESCs than that of the control group (7.7% versus 1.1%, P < 0.001). CONCLUSIONS: Altered apoptosis and proliferation of eutopic endometrium possibly elucidate some aspects of the pathophysiology of adenomyosis. A high Ki-67 labelling index in immunocytochemistry might be a potential indicator in predicting the occurrence of adenomyosis.

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Condition tags

mesh:D004715adenomyosis

MeSH descriptors

Apoptosis Endometriosis Endometrium Annexin A5 Annexin A5 Cell Proliferation Cell Separation Endometriosis Endometriosis Endometrium Endometrium Female Flow Cytometry Humans Hydrogen Peroxide Hydrogen Peroxide Immunohistochemistry Interferon-gamma Interferon-gamma Interleukin-6

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