Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis

Georgia M Lorentzen, Paweł Łaniewski, Haiyan Cui, Denise J Roe, Jamal Mourad, Nichole D Mahnert, Leslie V Farland, Melissa M Herbst-Kralovetz, Melissa M. Herbst‐Kralovetz
iScience · 2022 · vol. 25(12) , pp. 105508 · doi:10.1016/j.isci.2022.105508 · PMID:36419846 · W4308326737
article OA: gold CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Immunometabolic profiling of cervicovaginal lavages revealed distinct signatures, including altered cytokines and metabolites, in women with adenomyosis, highlighting pyrimidine and histidine metabolism alterations.

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Abstract

Adenomyosis is a burdensome gynecologic condition that is associated with pelvic pain, dysmenorrhea, and abnormal uterine bleeding, leading to a negative impact on quality of life; and yet is often left undiagnosed. We recruited 108 women undergoing hysterectomy for benign gynecologic conditions and collected non-invasive cervicovaginal lavage samples for immunometabolic profiling. Patients were grouped according to adenomyosis status. We investigated the levels of 72 soluble immune proteins and >900 metabolites using multiplex immunoassays and an untargeted global metabolomics platform. There were statistically significant alterations in the levels of several immune proteins and a large quantity of metabolites, particularly cytokines related to type II immunity and amino acids, respectively. Enrichment analysis revealed that pyrimidine metabolism, carnitine synthesis, and histidine/histamine metabolism were significantly upregulated pathways in adenomyosis. This study demonstrates utility of non-invasive sampling combined with immunometabolic profiling for adenomyosis detection and a greater pathophysiological understanding of this enigmatic condition.

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Condition tags

adenomyosisdysmenorrhea

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