The expression of Bcl-2 in adenomyosis and its effect on proliferation, migration, and apoptosis of endometrial stromal cells

Junyan Li, Li J, Yanyan M, Ma Yanyan, Lin Mu, Mu L, Chen X, Xuejun Chen, Wei Zheng, Zheng W
Pathology, research and practice · 2019 · vol. 215(8) , pp. 152477 · doi:10.1016/j.prp.2019.152477 · PMID:31174926 · W2946915636
Lab / animal OA: closed CC0 ⤵ 24 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study investigated Bcl-2 expression in adenomyosis and its impact on endometrial stromal cell proliferation, migration, and apoptosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Adenomyosis is a common gynecologic disease that severe impact on women. Previous studies have found that Bcl-2 abnormally expressed in adenomyosis. However, the exact mechanisms of Bcl-2 in the pathogenesis of adenomyosis are unclear. In this study, we are to explore the effect of Bcl-2 on proliferation, migration, and apoptosis of endometrial stromal cells. The expression of Bcl-2 were evaluated by Western blot and RT-qPCR. We used RNA interference to silence Bcl-2 gene of endometrial stromal cells, and then Cell Counting Kit(CCK-8), cell scratch repair test, and Annexin V-APC/propidium iodide (PI) staining were performed to detect the cell viability, migration ability and apoptotic rate. The results of the present study revealed that the expression of Bcl-2 was evidently higher than that in control group. After silencing the Bcl-2 gene, the cytoactive and migration ability of endometrial stromal cells of adenomyosis decreased, and the apoptotic rate increased. In conclusion, Bcl-2 is overexpressed in adenomyosis and participate in the pathogenesis of adenomyosis. Bcl-2 may be a potential novel target for adenomyosis treatment.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Apoptosis Cell Movement Proto-Oncogene Proteins c-bcl-2 Stromal Cells Adenomyosis Adenomyosis Adenomyosis Apoptosis Apoptosis Cell Movement Cell Movement Cell Movement Cell Proliferation Cell Proliferation Endometriosis Endometriosis Endometriosis Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (26)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:24:43.058907+00:00
unpaywall
last seen: 2026-10-15T06:24:24.424788+00:00
License: CC0 · commercial use OK