Human Reproduction

STUDY QUESTION: How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches? SUMMARY ANSWER: This exploration of the gut-reproductive axis in patients with endometriosis found…

The endometrium is a highly dynamic and complex tissue lining the uterus, playing a central role in reproductive health. Despite its importance, the pathogenesis of many benign endometrial disorders remains poorly understood, largely due to…

STUDY QUESTION: How does the frequency and location of endometriosis lesions observed at laparoscopy vary with patient age? SUMMARY ANSWER: We find that older patients have more deep lesions and ovarian endometriomas at laparoscopy, althou…

STUDY QUESTION: Are there histological and immunohistochemical patterns of superficial peritoneal endometriotic lesions of symptomatic patients that characterize non-response to dienogest treatment and may suggest progesterone resistance? …

STUDY QUESTION: Can patient-derived organoid models be reliably established from diverse surgical phenotypes of endometriosis, and how do clinical factors such as hormonal treatment affect their growth success and morphology? SUMMARY ANSWE…

STUDY QUESTION: Can a serum miRNA signature serve as a potential diagnostic biomarker for endometriosis (END)? SUMMARY ANSWER: A miRNA-based diagnostic model demonstrated an accuracy of 65.8% in distinguishing END patients from control sub…

Artificial intelligence (AI) is revolutionizing how we practice medicine. In areas where we have traditionally struggled, such as diagnosing endometriosis, AI has significant potential to improve the breadth and accuracy of diagnostic servi…

Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clini…

STUDY QUESTION: Does the restoration of regulatory T cells (Tregs) suppress the progression of endometriosis? SUMMARY ANSWER: Adoptive transfer of Tregs suppresses the progression of endometriosis and reduces the levels of helper T (Th)-ce…

STUDY QUESTION: Is childhood adversity associated with the subsequent diagnosis of endometriosis? SUMMARY ANSWER: Childhood adversities, including parental substance abuse, parental intellectual disability, parental psychiatric disorder, ha…

STUDY QUESTION: Can a large-scale genome-wide association study (GWAS) meta-analysis identify genomic risk loci and likely involved genes for female genital tract (FGT) polyps, provide insights into the biological mechanism underlying their…

STUDY QUESTION: How can we best achieve tissue segmentation and cell counting of multichannel-stained endometriosis sections to understand tissue composition? SUMMARY ANSWER: A combination of a machine learning-based tissue analysis softwa…

STUDY QUESTION: What is the association between endometriosis and the type and age of menopause? SUMMARY ANSWER: Women with endometriosis had a 7-fold increased risk of undergoing surgical menopause rather than natural menopause and were m…

STUDY QUESTION: What is the association between endometriosis and working life (lost), workforce participation, and productivity? SUMMARY ANSWER: Women with endometriosis experienced more working years lost due to disability pension and to…

STUDY QUESTION: Is patient consent to research associated with the distribution of population characteristics and study outcomes in ART cohort studies? SUMMARY ANSWER: The distribution of population characteristics in the patient consent s…

STUDY QUESTION: How does the burden of somatic disorders compare between women with surgically verified endometriosis diagnosed in adolescence or early adulthood, and matched women without a history of endometriosis? SUMMARY ANSWER: Women …

STUDY QUESTION: How is endometriosis care organized at the primary, secondary, and tertiary care levels in five high-income countries? SUMMARY ANSWER: In all countries under study, initiatives have been taken to provide endometriosis care …

STUDY QUESTION: How do cumulative live birth rates (CLBRs) in women with endometriosis compare to those with other infertility diagnoses undergoing ART? SUMMARY ANSWER: Women with endometriosis as the sole cause of infertility achieved high…

STUDY QUESTION: Does endometriosis and/or adenomyosis, diagnosed using the International Deep Endometriosis Analysis (IDEA) group and the Morphological Uterus Sonographic Assessment (MUSA) group revised definitions, impact cumulative live b…

STUDY QUESTION: Is there a difference in the use of endocrine endometriosis therapy in endometriosis patients with and without endometrioma? SUMMARY ANSWER: Patients with endometriomas received significantly less endocrine endometriosis tr…

STUDY QUESTION: Does endometriosis affect the mental health of women using oral contraceptives? SUMMARY ANSWER: Among oral contraceptive users, women with endometriosis have a higher risk of depression compared to those without endometrios…

STUDY QUESTION: Is there an association between pre-operative symptoms and intraoperatively described localization and size of endometriosis lesions as assessed by the #ENZIAN classification system? SUMMARY ANSWER: Dyschezia is associated w…

STUDY QUESTION: What are the profiles of body image (both negative and positive) and their associations with health-related quality of life (HRQoL) and endometriosis-related symptoms in women with endometriosis? SUMMARY ANSWER: Three distin…