Libo Zhu

Endometriosis, a prevalent gynecological disease affecting women's health, involves altered immune function. This study investigates the immune checkpoint protein, V-domain immunoglobulin suppressor of T cell activation (VISTA) as a therape…

BACKGROUND AND PURPOSE: Endometriosis is a chronic, hormone-dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is eff…

BACKGROUND: Extrinsic adenomyosis exhibits heterogeneous clinical symptoms, with pain being more commonly reported. The relationship between magnetic resonance imaging (MRI) feature and symptom remains unclear. OBJECTIVE: To evaluate the pe…

MOTIVATION: Normalization is a critical step in quantitative PCR (qPCR) and droplet digital PCR (ddPCR) experiments to ensure accurate and reproducible gene expression analysis. However, commonly used endogenous controls such as miR-16 for …

Endometriosis is a common yet often underdiagnosed condition, partly due to the lack of reliable diagnostics. This study examines the clinical feasibility of a blood-based, miRNA-driven test to diagnose endometriosis and address the challen…

Abstract Endometriosis is a common yet often underdiagnosed condition, partly due to the lack of reliable diagnostics. This study examines the clinical feasibility of a blood-based, miRNA-driven test to diagnose endometriosis and address th…

Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain po…

Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant l…

Pain is one of the main clinical symptoms of endometriosis, but its underlying mechanism is still not clear. Recent studies have shown that the secretory mediators of mast cells activated by estrogen are involved in the pathogenesis of endo…

Additional file 1. Clinical characteristics of endometriosis and control patients in this study.

Objective: To determine whether endometrioma recurrence is closely related to the presence of extrinsic adenomyosis, which was demonstrated by magnetic resonance imaging (MRI). Design: Observational crosssectional study involving patients w…

Objective: This study aims to evaluate the factors associated with complications and long-term results in the surgical treatment of intestinal deep endometriosis and to figure out the optimized treatment measures for bowel endometriosis. Me…

This investigation probed endometriosis treatment using targeted nanoparticles (NPs) to modulate autophagic activity. To that end, a novel form of polymer-based NP gene delivery platform consisting of polyethyleneimine (PEI) conjugated to s…

Objective: To study the 12-month effects and possible mechanisms of low-dose mifepristone in the treatment of adenomyosis. Methods: Patients included in this retrospective study had painful adenomyosis and previously received 5 mg mifeprist…

Triptorelin is one of the most commonly used gonadotropin-releasing hormone agonists and has been used in the treatment of deep infiltrating endometriosis (DIE). This study aimed to evaluate the efficacy and safety of up to 24 weeks of trip…

BACKGROUND: Many factors can affect the recurrence of endometriosis after surgery, however, whether endometriotic cyst fluid contributes to endometriosis recurrence after surgical excision of ovarian endometriomas remains unclear. The objec…

Additional file 10: Table S9. List of differential genes in subtypes of mast cells.

Additional file 2: Table S1. Clinical characteristics of endometriosis and control patients in this study.

Additional file 3: Table S2. Genes, UMIs counts, percentage of hemoglobin gene and percentage of mitochondrion for each individual cell.

Additional file 4: Table S3. The mean gene expression in each cluster of endometriosis (EMs) and control samples.

Additional file 5: Table S4. List of markers information for each cluster in ascites cells.