PloS one

Chronic visceral pain affects over 20% of adults globally but remains poorly understood, significantly impacting quality of life and healthcare costs. Limited understanding and diagnostic misconceptions hinder effective management, particul…

OBJECTIVE: To evaluate the behavioral and clinical characteristics of endometriosis patients at the largest tertiary healthcare center in Lebanon and to analyze the effect of endometriosis symptoms, age of menarche, sexual activity, and inf…

BACKGROUND: Infertility affects millions globally, and while assisted reproductive technology (ART) has become a cornerstone of its treatment, there is limited research on how Lebanese women perceive these services. This study aims to fill …

Women's reproductive and endocrine disorders including Polycystic Ovary Syndrome (PCOS), endometriosis, thyroid disorders, infertility, and pregnancy-related complications remain a major global health burden. These conditions are especially…

BACKGROUND: Dysmenorrhea is the most common menstrual disorder among young women and often disrupts daily activities and well-being. Although pharmacological management is widely used, sustainable non-pharmacological strategies remain under…

BACKGROUND: Polycystic Ovary Syndrome (PCOS) is one of the most common conditions affecting women of reproductive age, significantly impacting both physical and psychological well-being, often leading to depressive symptoms and lower body i…

Cervical conization is the standard treatment for cervical intraepithelial neoplasia. However, its effects on pregnancy outcomes remain controversial. Using data from the Korean National Health Insurance System, this population-based retros…

BACKGROUND: To investigate the association between menstrual-related disorders and sexually transmitted infections (STI) among young women in Japan, and to examine differences according to disorder type and hormonal therapy use. METHODS: T…

OBJECTIVE: This study aimed to investigate the association between body mass index (BMI) and sexual function, measured by the Female Sexual Function Index (FSFI), in women with endometriosis, adjusting for the number of endometriosis sympto…

Conventional in vitro fertilization (IVF) outcome prediction is limited by static, single-endpoint analyses. We aimed to overcome this by using a multistate model to dissect the stage-specific and, crucially, the non-linear influence of end…

BACKGROUND: Ferritin may be elevated as an acute-phase reactant in inflammatory conditions, potentially masking iron deficiency. We aimed to evaluate the frequency of iron deficiency and the diagnostic significance of transferrin saturation…

Endometriosis and ovarian cancer share invasive, inflammatory, and pro-survival mechanisms in which CXCR4 signaling may play an important role, yet phytochemical modulators of this receptor remain insufficiently characterized. This study ad…

[This corrects the article DOI: 10.1371/journal.pone.0057724.].

A new humoral factor has been detected, within a project aiming to disclose the body's reproductive hormonal brake against tissue overgrowth, micrin ('my-crin'). Factor purification involved fractionation of ovine and bovine ovarian follicu…

BACKGROUND: Placenta accreta spectrum (PAS), an abnormal placental invasion into the myometrium or beyond the uterine serosa, is associated with adverse pregnancy outcomes. Placenta previa is the most significant individual risk factor for …

OBJECTIVE: This scoping review aimed to map the evidence on how digital health technologies are used for pain management in endometriosis. METHODS: This scoping review adhered to the Joanna Briggs Institute methodological framework and fol…

The window of implantation is a critical period for embryo implantation. Ovarian stimulation can disrupt endometrial receptivity, potentially through altered gene expression and downstream protein profiles. However, the impact on the endome…

BACKGROUND: The presence of hypoechoic cystic lesions (HCL) within the endometrium has been proposed as a potential factor influencing implantation and pregnancy outcomes during frozen-thawed embryo transfer (FET) cycles. However, evidence …

BACKGROUND: Endometriosis is a complex gynecological condition characterized by endometrial tissue growing outside the uterus. In many in vitro studies, almost all progestins have indicated the anti-proliferation and apoptosis of endometrio…

BACKGROUND AND OBJECTIVE: Dysmenorrhea, painful menstruation, affects 20-90% of women and it can significantly impair their quality of life. To evaluate the severity and consequences of dysmenorrhea specific questionnaires have been develop…

OBJECTIVE: The aim of this study was to compare the therapeutic efficacy of integrating virtual reality technology with conventional pelvic floor rehabilitation therapy versus conventional therapy alone in postpartum women with myofascial p…

BACKGROUND: Hysterectomy is a common gynecological surgery, but its long-term impact on ovarian cancer risk remains unclear, particularly in Asian populations. OBJECTIVE: To evaluate the association between hysterectomy (with or without co…

UNLABELLED: Antipsychotic medications can cause serious metabolic adverse effects, including type 2 diabetes, with females disproportionally more affected than males. Recently, brain insulin resistance (IR) has been posited as a potential d…

AIMS: The aim of this study was to investigate the mechanism of action of SB on TRP-induced abnormalities of bone metabolism in LNCaP cells. METHODS: The effects of different concentrations of SB and TRP alone and in combination on the pro…