Frontiers in immunology

Gynecologic diseases, including infectious disorders, endocrine-related conditions, gynecologic malignancies, and pregnancy complications, are clinically diverse yet frequently share features of hormonal imbalance, microbial dysbiosis, and …

INTRODUCTION: SLE is a chronic autoimmune disease characterized by immune system dysregulation, including aberrant activation of B and T lymphocytes and overproduction of proinflammatory cytokines such as IL-21. Through the STAT3 signaling …

PURPOSE: This study investigated the contribution of peritoneal macrophages to tumor control using a DBA/2-SL2 murine model of concomitant tumor immunity. METHODS: Female DBA/2 mice were subjected to a concomitant tumor model in which SL2 …

Exosomes serve as crucial mediators of intercellular communication, regulating cellular functions by carrying proteins, nucleic acids, and lipids. As core components of the immune system, macrophages are closely associated with exosomes. Th…

BACKGROUND: Ovarian cancer remains one of the deadliest gynecologic malignancies. Poor outcomes largely reflect late diagnosis, marked inter- and intratumoral heterogeneity, and variable treatment response. METHODS: This review summarizes …

A 37-year-old non-Caucasian woman presented with a 2-year history of pruritic, concentric erythematous plaques refractory to multiple topical and systemic therapies. The clinical findings were highly suggestive of erythema gyratum repens (E…

BACKGROUND: Metformin (MET), a widely used antidiabetic agent, and parthenolide (PAR), a natural compound recognized for its anti-inflammatory properties, have both been extensively explored for their anticancer potential. The present study…

Chronic inflammation underlies a broad range of human diseases, including autoimmune disorders, neurodegeneration, and metabolic syndromes. While acute inflammation is essential for pathogen clearance and tissue repair, persistent activatio…

Endometriosis is a prevalent chronic inflammatory gynecological disorder affecting approximately 10% of reproductive-age women worldwide, characterized by endometrial-like tissue outside the uterine cavity. Ectopic lesion growth tracks clos…

BACKGROUND: Endometriosis is frequently associated with impaired fertility. Metabolic abnormalities and dyslipidemia may be relevant to reproductive dysfunction among women with endometriosis; however, their associations with subsequent rep…

OBJECTIVE: The cervicovaginal microenvironment, influenced by factors such as pH and cytokine profiles, plays a critical role in cervical remodeling, membrane rupture, and uterine contractions, key processes in maintaining pregnancy and tri…

INTRODUCTION: Endometrial receptivity is essential for implantation in both natural and ART cycles, yet the cellular and molecular environment of the endometrium during this window remains poorly characterized. While cytokines affecting imp…

Although antibiotic therapy effectively cures active tuberculosis (TB), many survivors are left with permanent lung damage and long-lasting immune alterations. Growing epidemiological evidence indicates that individuals with prior pulmonary…

Endometriosis (EMS) is a highly heterogeneous chronic gynecological disease characterized by pain, infertility, and relapse, with its etiology and pathogenesis not yet fully elucidated. Traditional theories, including "retrograde menstruati…

Frozen shoulder (FS) is a condition primarily marked by chronic inflammation and progressive fibrosis of the glenohumeral capsule. Clinically, it presents with persistent shoulder pain and limited joint mobility, often leading to impaired u…

Endometriosis (EMs) is a common estrogen-dependent inflammatory disease characterized by pelvic pain and infertility. Despite its substantial clinical burden, its etiology and pathogenesis remain incompletely resolved, and current managemen…

Vasohibin-1 (VASH-1) is an endothelial protein that serves as a negative feedback regulator of angiogenesis. Through its microtubule carboxypeptidase activity, VASH-1 plays a key role in vascular homeostasis. While previous studies have inv…

Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and surviva…

The survival of ectopic endometrial lesions in endometriosis critically depends on their ability to evade immune recognition and clearance by the host, a process known as immune evasion. Recent studies suggest that this process is not drive…