Journal of pain research

BACKGROUND: Acupuncture combined with herbal cake-separated moxibustion may be an effective treatment option for chronic pelvic pain (CPP) in sequelae of pelvic inflammatory disease (SPID), yet safety and feasibility evidence remain scarce.…

PURPOSE: Vaginal delivery is the most common mode of childbirth, and women often experience severe uterine contraction pain (UCP) for several days postpartum, which can significantly impair postpartum recovery. Acupuncture has proven effica…

BACKGROUND: Primary dysmenorrhea (PDM), as a form of chronic pelvic pain, has a complex pathophysiology involving hormonal factors, central nervous system alterations, and maladaptive pain cognition. Previous neuroimaging studies have demon…

BACKGROUND: Endometriosis, characterized by dysmenorrhea and pelvic pain, is a common gynecological disease. Acupuncture, as a complementary and alternative therapy for endometriosis, has been supported by a large body of clinical evidence.…

BACKGROUND: Primary dysmenorrhoea is common and disabling, while available treatments may be limited by incomplete response or adverse effects. We aimed to evaluate the efficacy and safety of Guizhi Fuling Capsules (GZFL) for primary dysmen…

BACKGROUND: Fibromyalgia may be documented after years of regional pain, but the localized presentations associated with subsequent fibromyalgia documentation in pain-clinic practice remain poorly defined. Documentation in health records ma…

BACKGROUND: Endometriosis is a chronic gynecological disorder characterized by pain and impaired quality of life (QoL). While pharmacological and surgical options exist, their limitations necessitate complementary strategies. The comparativ…

OBJECTIVE: To identify core acupoint prescription patterns for primary dysmenorrhea (PD) using data mining and to generate hypothesis-level mechanistic insight through network-based analysis. METHODS: Nine Chinese and English databases wer…

BACKGROUND: Primary dysmenorrhea is fundamentally driven by uterine ischemia resulting from excessive vascular resistance. While acupuncture is theorized to improve perfusion, high-quality evidence controlling for pharmacological confounder…

OBJECTIVE: To identify the risk factors for severe primary dysmenorrhea in adolescent girls and provide evidence for clinical prevention and intervention. METHODS: This retrospective study enrolled adolescent girls with primary dysmenorrhe…

PURPOSE: Adenomyosis, a common gynecologic condition of the uterus, affects women with diverse symptoms including pain. Traditionally evaluated pathologically, advanced imaging modality has led to more diagnoses including asymptomatic women…

PURPOSE: Body perception disturbances, such as distorted perception of limb size, are well documented in specific pain conditions like complex regional pain syndrome but remain underexplored in chronic pain more broadly. This qualitative st…

BACKGROUND: Endometriosis (EMS) is characterized by pain symptoms that seriously affect patients' quality of life. Gut microbiome-related metabolites (GMRM) play an important role in the process of EMS. However, the role of GMRM in endometr…

PURPOSE: Pain-related fear (PRF) is increasingly recognized as a clinically relevant psychological factor in chronic pain, yet its role in attentional processing across varying threat levels remains unclear, particularly in functional visce…

Migraine is a highly prevalent and disabling neurological disorder with multiple hypotheses regarding its pathogenesis. G protein-coupled receptor 30 (GPR30), a member of the G protein-coupled receptor family, was once considered a membrane…

PURPOSE: To evaluate prediction models for acute postoperative pain (AOPP) and chronic postsurgical pain (CPSP) after cancer surgery, prioritizing pain phenotype and cancer type. PATIENTS AND METHODS: Four databases were searched through F…

PURPOSE: To evaluate whether preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with early postoperative pain burden and PCA-derived opioid requirement after laparoscopic gynecologic surgery. METHODS: In this prospective obser…

BACKGROUND: Endometriosis is a leading cause of chronic pelvic pain (CPP), but the public transcriptomic datasets analysed here contain no pain phenotype, links to CPP are therefore hypothesis-generating. METHODS: We re-analysed GSE153739 …

Pain assessment is fundamental in pain medicine, anesthesiology, perioperative care, and clinical trials, yet it remains difficult to standardize across diseases, populations, and care settings. This review organizes pain assessment into fo…

OBJECTIVE: This study aimed to evaluate the impact of succinylcholine on the incidence of postoperative sore throat (POST) in patients undergoing hysteroscopy under laryngeal mask airway (LMA)-assisted general anesthesia. DESIGN: A prospec…

BACKGROUND: This network meta-analysis (NMA) aimed to explore the impact of Non-pharmacological therapies (NPT) on alleviating primary dysmenorrhea (PD) symptoms and assess the effectiveness differences among various NPT. METHODS: We searc…