Dienogest and the Risk of Endometriosis Recurrence Following Surgery: A Systematic Review and Meta-analysis

Andrew Zakhari; Darl Edwards; D.L. Edwards; Michelle Ryu; John J Matelski; John Matelski; Olga Bougie; Ally Murji

doi:10.1016/j.jmig.2020.05.007

Dienogest and the Risk of Endometriosis Recurrence Following Surgery: A Systematic Review and Meta-analysis

Andrew Zakhari, Darl Edwards, D.L. Edwards, Michelle Ryu, John J Matelski, John Matelski, Olga Bougie, Ally Murji

Journal of minimally invasive gynecology · 2020 · vol. 27(7) , pp. 1503–1510 · doi:10.1016/j.jmig.2020.05.007 · PMID:32428571 · W3025366094

review OA: closed CC0 ⤵ 55 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This systematic review and meta-analysis assessed the impact of dienogest on endometriosis recurrence rates after surgical intervention.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Nandrolone Combined Modality Therapy Endometriosis Endometriosis Female Humans Incidence Nandrolone Nandrolone Observational Studies as Topic Observational Studies as Topic Randomized Controlled Trials as Topic Randomized Controlled Trials as Topic Recurrence Risk Factors Secondary Prevention Secondary Prevention

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References (43)

Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside via openalex
Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma via openalex
Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study via openalex
Comparison of complete and incomplete excision of deep infiltrating endometriosis. via openalex
Comparison of Complete and Incomplete Excision of Deep Infiltrating Endometriosis via openalex
Diagnosis and management of endometriosis: summary of NICE guidance via openalex
Dienogest compared with gonadotropin‐releasing hormone agonist after conservative surgery for endometriosis via openalex
Dienogest in long-term treatment of endometriosis via openalex
Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis via openalex
Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries via openalex
East and South East Asian Ethnicity and Moderate-to-Severe Endometriosis via openalex
Effect of dienogest on pain and ovarian endometrioma occurrence after laparoscopic resection of uterosacral ligaments with deep infiltrating endometriosis via openalex
Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex
Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months via openalex
Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma via openalex
Elagolix: First Global Approval via openalex
Gonadotropin-releasing hormone agonist with add–back treatment is as effective and tolerable as dienogest in preventing pain recurrence after laparoscopic surgery for endometriosis via openalex
Long-Term Administration of Dienogest Reduces Recurrence after Excision of Endometrioma via openalex
Operative management of deeply infiltrating endometriosis: Results on pelvic pain symptoms according to a surgical classification via openalex
Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference? via openalex
Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas via openalex
Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III–IV: a randomized controlled trial via openalex
Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex
Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex
Pre and post-operative medical therapy for endometriosis surgery via openalex
Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis via openalex
Recurrence of ovarian endometrioma after laparoscopic excision: Risk factors and prevention via openalex
The pharmacological profile of dienogest via openalex
[Therapy of endometriosis with dienogest]. via openalex
Use of dienogest in endometriosis: a narrative literature review and expert commentary via openalex
Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis via openalex
When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement via openalex
W2132577372 via openalex
W2045458073 via openalex
W2947876135 via openalex
W4362504902 via openalex
W6682765475 via openalex
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Cited by (50)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:21:59.141895+00:00

License: CC0 · commercial use OK

[1] Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside via openalex

[2] Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma via openalex

[3] Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study via openalex

[4] Comparison of complete and incomplete excision of deep infiltrating endometriosis. via openalex

[5] Comparison of Complete and Incomplete Excision of Deep Infiltrating Endometriosis via openalex

[6] Diagnosis and management of endometriosis: summary of NICE guidance via openalex

[7] Dienogest compared with gonadotropin‐releasing hormone agonist after conservative surgery for endometriosis via openalex

[8] Dienogest in long-term treatment of endometriosis via openalex

[9] Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis via openalex

[10] Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries via openalex

[11] East and South East Asian Ethnicity and Moderate-to-Severe Endometriosis via openalex

[12] Effect of dienogest on pain and ovarian endometrioma occurrence after laparoscopic resection of uterosacral ligaments with deep infiltrating endometriosis via openalex

[13] Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex

[14] Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months via openalex

[15] Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma via openalex

[16] Elagolix: First Global Approval via openalex

[17] Gonadotropin-releasing hormone agonist with add–back treatment is as effective and tolerable as dienogest in preventing pain recurrence after laparoscopic surgery for endometriosis via openalex

[18] Long-Term Administration of Dienogest Reduces Recurrence after Excision of Endometrioma via openalex

[19] Operative management of deeply infiltrating endometriosis: Results on pelvic pain symptoms according to a surgical classification via openalex

[20] Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference? via openalex

[21] Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas via openalex

[22] Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III–IV: a randomized controlled trial via openalex

[23] Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex

[24] Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex

[25] Pre and post-operative medical therapy for endometriosis surgery via openalex

[26] Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis via openalex

[27] Recurrence of ovarian endometrioma after laparoscopic excision: Risk factors and prevention via openalex

[28] The pharmacological profile of dienogest via openalex

[29] [Therapy of endometriosis with dienogest]. via openalex

[30] Use of dienogest in endometriosis: a narrative literature review and expert commentary via openalex

[31] Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis via openalex

[32] When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement via openalex

[33] W2132577372 via openalex

[34] W2045458073 via openalex

[35] W2947876135 via openalex

[36] W4362504902 via openalex

[37] W6682765475 via openalex

[38] W6688745209 via openalex

[39] W6714496033 via openalex

[40] W2586772905 via openalex

[41] W6825204538 via openalex

[42] W1598602811 via openalex

[43] W2157449760 via openalex