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Endometriosis (EM) is a heterogeneous, gynecological inflammatory disease affecting over 200 million individuals worldwide, yet the mechanisms underlying lesion establishment, progression, and recurrence remain incompletely understood. Smal…

OBJECTIVE: To provide health care professionals with an evidence-based approach to the management of endometriosis and its associated symptoms. TARGET POPULATION: Women and gender-diverse individuals affected by endometriosis. BENEFITS, H…

OBJECTIVE: Canadians with endometriosis experience significant delays in access to care within our national health care system. This study aims to discern the factors leading individuals with suspected and/or confirmed endometriosis to seek…

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STUDY OBJECTIVE: This study aimed to evaluate the association between surgeon characteristics and postoperative surgical outcomes, including rates of complications, recurrence of symptoms, fertility outcomes, and need for reoperation for in…

Endometriosis is a chronic inflammatory condition that has been linked to mental health outcomes. We conducted a population-based, retrospective, matched cohort study using administrative health data (2010-2022) from Ontario, Canada, to ass…

BACKGROUND: Endometriosis is a chronic gynecologic disorder that leads to considerable pain and a reduced quality of life. Although its physiological manifestations have been explored, its impact on mental health is less well defined. Exist…

This population-based cohort evaluated the association between endometriosis and severe maternal morbidity (SMM), and the mediating effect of infertility and fertility treatment. Included were all singleton deliveries in Ontario between 200…

OBJECTIVE: To provide a contemporary approach to the understanding of the impact and methods for the diagnosis of endometriosis in Canada. TARGET POPULATION: Individuals, families, communities, health care providers, and health care admini…

Endometriosis is a chronic inflammatory disease in which endometrial-like tissue grows ectopically, resulting in pelvic pain and infertility. IL-23 is a key contributor in the development and differentiation of TH17 cells, driving TH17 cell…

BACKGROUND: Endometriosis is a common gynecological condition with a wide range of symptoms, including infertility, dyspareunia, intestinal disorders, and pelvic pain. Laparoscopy and laparotomy are used widely for diagnosing and managing e…

BACKGROUND: A significant proportion of patients with endometriosis require surgery for management of the disease. AIMS: We aimed to assess the trend and regional variation in day surgeries for endometriosis across Canada and to identify p…

OBJECTIVES: Endometriosis is a common gynaecologic disease for which surgery is often required. Our objective was to evaluate the potential determinants of perioperative complications in day-surgeries for endometriosis. METHODS: We conduct…

Dysmenorrhea is the most common gynecologic condition among the female population and has a significant impact on life course potential. It has a widespread impact on a female's mental and physical well-being, with longstanding impairments …

Brittany MacGregor,1 Catherine Allaire,1 Mohamed A Bedaiwy,1 Paul J Yong,1,* Olga Bougie2,* 1Department of Obstetrics and Gynaecology, University of British Columbia, BC Women’s Centre for Pelvic Pain and Endometriosis, Vancouver, Canada; 2…

BACKGROUND: Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to e…

Endometriosis is an estrogen dominant, chronic inflammatory disease characterized by the growth of endometrial-like tissue outside of the uterus. The most common symptoms experienced by patients include manifestations of chronic pelvic pain…

We investigated the validity of the 10th Revision Canadian modification of International Statistical Classification of Disease and Related Health Problems (ICD-10-CA) diagnostic codes for surgery for benign gynaecologic conditions in the Ca…

OBJECTIVE: To evaluate the association between endometriosis and adverse pregnancy outcomes. DESIGN: Population-based retrospective cohort study using linked universal health databases through ICES Ontario. PATIENT(S): All singleton pregn…

Chronic inflammation and localized alterations in immune cell function are suspected to contribute to the progression of endometriosis and its associated symptoms. In particular, the alarmin IL-33 is elevated in the plasma, peritoneal fluid…

OBJECTIVE: To evaluate differences in quality metrics between hysterectomies performed by fellowship-trained surgeons and those performed by generalists. METHODS: Retrospective review of 2845 consecutive hysterectomies by 75 surgeons (23 f…

BACKGROUND: Endometriosis is a chronic gynecological disease affecting approximately 10% of reproductive aged females and leads to decreased quality of life and productivity. Despite effective medical options, many women do require surgery …