1,25-Dihydroxy vitamin D 3 inhibits LPS-mediated inflammatory responses in endometriosis
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1,25-dihydroxy vitamin D3 inhibited endometriosis lesion growth and suppressed LPS-mediated inflammatory responses by stabilizing IκBα and activating the VDR.
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Abstract
BACKGROUND: Endometriosis, a chronic immune-mediated inflammatory disease, remains elusive in its pathogenesis. Given vitamin D (VD)'s pivotal role in modulating innate and adaptive immune responses, we sought to elucidate how VD modulates inflammatory responses in endometriosis. MATERIALS AND METHODS: -26,23-lactone). RESULTS: significantly inhibited lesion growth, suppressed NF-κB pathway activation, and corresponding inflammatory phenotypes in a rat model of endometriosis. CONCLUSIONS: VDR-dependent endometrial homeostasis regulation, suppressing LPS-mediated inflammatory responses and NF-κB signaling pathway through VDR activation and IκBα stabilization.
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