Lipopolysaccharide promotes the development of murine endometriosis-like lesions via the nuclear factor-kappa B pathway

Azuma Y, Yukihiro Azuma, Fuminori Taniguchi, Taniguchi F, Nakamura K, Kazuomi Nakamura, Nagira K, Kei Nagira, Khine YM, Yin Mon Khine, Tomoiki Kiyama, Kiyama T, Takashi Uegaki, Uegaki T, Masao Izawa, Izawa M, Harada T, Tasuku Harada
American journal of reproductive immunology (New York, N.Y. : 1989) · 2017 · vol. 77(4) · doi:10.1111/aji.12631 · PMID:28138997 · W2584002740
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Lipopolysaccharide administration increased the number, size, and inflammatory marker expression of endometriosis-like lesions in mice, which was reversed by an NF-κB inhibitor.

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Abstract

PROBLEM: Is lipopolysaccharide (LPS) involved in the development of endometriosis? METHOD OF STUDY: BALB/c mice (n=69) were used for the murine endometriosis model. Mice with surgically induced endometriosis were injected with LPS intraperitoneally. After 4 weeks of LPS injections with or without the nuclear factor-kappa B (NF-κB) inhibitor, the extent of endometriosis-like lesions was evaluated. Expression of inflammatory factors in the implants was evaluated using real-time RT-PCR. Cell proliferation, angiogenic activity, inflammation, and NF-κB phosphorylation were assessed by immunohistochemical staining. RESULTS: Lipopolysaccharide increased total number, size, and mRNA expression of Ptgs-2, Vegf, Ccl-2, and Il-6 in endometriosis-like lesions. LPS also increased the percentage of Ki67-positive cells and enhanced the intensity and rate of positive cells of CD3, F4/80, and PECAM. Intense expression of phospho-NF-κB p65 after LPS administration was observed. Treatment with the NF-kB inhibitor negated these LPS-induced effects. CONCLUSION: LPS-induced pelvic inflammation status enhanced the development of murine endometriosis-like lesions via NF-κB pathway.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lipopolysaccharides NF-kappa B Signal Transduction Animals Animals Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Female Immunohistochemistry Immunohistochemistry Inflammation Inflammation Inflammation Inflammation Inflammation

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