Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-28 ⓘ

This study investigated associations between estrogen receptor gene polymorphisms and the recurrence of endometriosis in affected patients.

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Abstract

The presence of gene polymorphisms of the estrogen receptors ERalpha (PvuII and XbaI) and ERbeta (AluI) in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ERalpha gene polymorphism (PvuII), both in homozygosity (PP) and in heterozygosity (Pp), and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ERalpha polymorphic allele, even if heterozygous, have a worse prognosis, and these results suggest that the ERalpha gene polymorphisms may be included among the genetic risk factors for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogen Receptor alpha Polymorphism, Genetic Polymorphism, Genetic Adult Adult Alleles Alleles Case-Control Studies Case-Control Studies Endometriosis Endometriosis Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor beta Estrogen Receptor beta Estrogen Receptor beta Female Female Gene Frequency

Citation neighborhood

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References (11)

Cited by (36)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:03:37.664955+00:00
License: CC0 · commercial use OK