Genetic factors related to endometriosis: present and future

Anna Maria Di Blasio, Edgardo Somigliana, Paola Viganò
In: Expert Review of Obstetrics & Gynecology · 2007 · vol. 2(6) , pp. 791–801 · doi:10.1586/17474108.2.6.791 · W2124847401
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews current research on identifying genetic variations associated with endometriosis susceptibility and discusses future directions for understanding pathogenesis and developing personalized therapies.

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Abstract

Endometriosis is a multifactorial disease that affects 6–10% of women of reproductive age. Epidemiological studies indicate that it is a polygenic disorder, with recurrence risks in first-degree relatives of approximately 2–9%. Thus, the current task of different research groups is to identify genetic variations in an obvious candidate gene that could be associated with an increased susceptibility to endometriosis. The great advancement in molecular biology techniques certainly make this task possible, although particular attention needs to be paid to study design in order to achieve solid results. The data obtained by such studies will allow us to expand our knowledge of the pathogenesis of the disease and, more importantly, develop individualized therapies and prevention strategies to apply to high-risk populations.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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