Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis

Zhang X, X. Zhang, P Hei, Peter Hei�, Hei P, Lin Deng, L Deng, Deng L, Lin J, Jun Lin, J Lin
Molecular human reproduction · 2006 · vol. 13(2) , pp. 135–140 · doi:10.1093/molehr/gal106 · PMID:17178764 · W2153394923
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This study found increased frequency of IL-10 gene promoter polymorphisms at -819 or -592 and higher IL-10 protein levels in peritoneal fluid of endometriosis patients compared to controls.

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Abstract

Although associations of interleukin-10 (IL-10) gene promoter polymorphisms and their protein production with endometriosis risk have been reported, the correlations remain controversial. The objective of this study was to determine IL-10 gene promoter polymorphisms at -1082, -819 and -592 sites and their protein production in peritoneal fluid (PF) in patients with and without endometriosis. IL-10 gene promoter polymorphisms at -1082 site were detected by amplification refractory mutation system (ARMS)-PCR and that at -819 and -592 sites was genotyped by restriction fragment length polymorphism (RFLP)-PCR. Protein levels of IL-10 in PF were measured by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in the genotype and allele frequencies of IL-10 gene promoter polymorphisms at position -1082 between the endometriosis and the control groups. However, the frequency of -819 or -592 C alleles was significantly increased in patients with endometriosis compared with controls. The protein levels of IL-10 in PF were statistically higher in the endometriosis group than in the control group. Moreover, the polymorphisms at -1082, -819 and -592 sites were associated with protein levels of IL-10 in PF in the endometriosis group while in the control group only the polymorphisms at position -1082 correlated with protein levels. Increased frequency of -819 or -592 C allele and increased protein production of IL-10 in PF in patients with endometriosis compared with controls and correlations of polymorphisms at -819 and -592 sites with protein levels of IL-10 in PF in patients with endometriosis may suggest that polymorphisms at -819 and -592 sites and their protein production are associated with endometriosis risk.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Interleukin-10 Interleukin-10 Promoter Regions, Genetic Promoter Regions, Genetic Ascitic Fluid Ascitic Fluid Ascitic Fluid Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Haplotypes

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References (39)

Cited by (26)

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