Challenges in endometriosis miRNA studies — From tissue heterogeneity to disease specific miRNAs

Merli Saare, Kadri Rekker, Triin Laisk-Podar, Nilüfer Rahmioğlu, Nilufer Rahmioglu, Krina Zondervan, Krina T. Zondervan, Andres Salumets, Martin Götte, Maire Peters
Biochimica et biophysica acta. Molecular basis of disease · 2017 · vol. 1863(9) , pp. 2282–2292 · doi:10.1016/j.bbadis.2017.06.018 · PMID:28651916 · W2715074302
review OA: green CC0 ⤵ 62 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This review examines endometriosis miRNA studies, highlighting how tissue heterogeneity, from whole lesions to isolated cells, may explain the low concordance of reported disease-specific microRNAs.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text ⓘ

This review examines microRNA (miRNA) studies in endometriosis, including analyses of endometriotic lesions, endometrial biopsies, and isolated stromal or epithelial cell fractions, which have collectively reported many dysregulated miRNAs. It highlights that concordance across studies is low, and proposes tissue composition heterogeneity as a key reason, noting that comparisons range from whole heterogeneous lesion biopsies to endometrium from patients versus controls and to purified cell fractions. The paper also summarizes functional studies aimed at characterizing roles of miRNAs implicated in endometriosis. This paper is centrally about endometriosis — it reviews miRNA findings and argues that tissue heterogeneity contributes to discrepancies in identifying disease-specific endometriosis miRNA alterations.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 1,318 characters · extracted from oa-html · 2 sections · click to expand

Abstract

In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these tissues have been investigated and a large number of dysregulated miRNAs have been reported. However, the concordance between the result of different studies has remained small. One potential explanation for limited overlap between the proposed disease-related miRNAs could be the heterogeneity in tissue composition, as some studies have compared highly heterogeneous whole-lesion biopsies with endometrial tissue, some have compared the endometrium from patients and controls, and some have used pure cell fractions isolated from lesions and endometrium. This review focuses on the results of published miRNA studies in endometriosis to reveal the potential impact of tissue heterogeneity on the discovery of disease-specific miRNA alterations in endometriosis. Additionally, functional studies that explore the roles of endometriosis-involved miRNAs are discussed. Description

Keywords

Endometriosis, Endometrium, MicroRNA, Microarray, Stroma, Tissue heterogeneity

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Regulation MicroRNAs Animals Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans MicroRNAs MicroRNAs

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:20:25.745717+00:00
License: CC0 · commercial use OK