Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis

Josep Marí‐Alexandre, Josep Marí-Alexandre, Antonio Pellín Carcelén, Amador CARCELEN, Cristina Agababyan, Andrea Moreno‐Manuel, Javier García-Oms, Silvia Calabuig‐Fariñas, Juan Gilabert–Estellés
International journal of molecular sciences · 2019 · vol. 20(21) , pp. 5322 · doi:10.3390/ijms20215322 · PMID:31731537 · W2981799501
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This review explores the interplay between microRNAs and oxidative stress in the pathophysiology of ovarian cancer and endometriosis, highlighting their roles in disease development and chemoresistance.

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Abstract

Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19-22 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion development and fallopian tube malignant transformation leading to high-grade serous ovarian cancer (HGSOC). Furthermore, as HGSOC develops, increased OS levels are associated with chemoresistance. Finally, continued bleeding within ovarian endometrioma raises OS levels and contributes to the development of endometriosis-associated ovarian cancer (EAOC). Therefore, this review aims to address the need for a better understanding of the dialogue between miRNAs and oxidative stress in the pathophysiology of ovarian conditions: endometriosis, EAOC and HGSOC.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Oxidative Stress RNA, Neoplasm RNA, Neoplasm RNA, Neoplasm Animals Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (12)

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