Increased circulating T helper 17 (TH17) cells and endometrial tissue IL-17-producing cells in patients with endometriosis compared with non-endometriotic subjects

Ali-Akbar Delbandi, Ali‐Akbar Delbandi, Mahmoud Mahmoudi, Adel Shervin, Pooya Farhangnia, Tahereh Mohammadi, Amir‐Hassan Zarnani, Amir-Hassan Zarnani
Reproductive biology · 2025 · vol. 25(2) , pp. 101019 · doi:10.1016/j.repbio.2025.101019 · PMID:40222069 · W4409383005
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis patients exhibit elevated circulating T helper 17 cells and increased IL-17-producing cells in both eutopic and ectopic endometrial tissues compared to non-endometriotic subjects.

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Abstract

17 and IL-17-producing lymphocytes was significantly higher in the PBMCs of patients with endometriosis compared to non-endometriotic subjects (P < 0.01 and P < 0.001, respectively). The expression of IL-17 protein in ectopic (P < 0.001) and eutopic (P < 0.05) endometrial tissues of patients with endometriosis increased compared to controls' endometrial tissue. Furthermore, the eutopic endometrium of patients with endometriosis showed a higher expression of IL-17 protein than the eutopic endometrial tissue of control subjects (P < 0.05). The findings suggest that the higher frequency of IL-17-producing cells in the PBMCs and endometrial tissues of patients with endometriosis contributes to the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (60)

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