Endometriosis and Infertility

Kristin Holoch, Kristin J Holoch, Bruce A Lessey
Clinical obstetrics and gynecology · 2010 · vol. 53(2) , pp. 429–438 · doi:10.1097/grf.0b013e3181db7d71 · PMID:20436320 · W2985833654
article OA: closed CC0 ⤵ 199 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis, affecting up to 10% of reproductive-aged women, is strongly associated with infertility, with surgical treatment showing cost-effectiveness and potential for improved fecundity, while medical management's efficacy is unproven outside IVF.

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Abstract

Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Up to 50% of women with endometriosis are infertile, and agreement about treatment options has been difficult to establish. The association between endometriosis and infertility is derived from comparisons of fertile and infertile women, animal models, donor sperm studies, and in vitro fertilization results. Diagnostic approaches based on endometrial changes associated with endometriosis are also providing insights into possible mechanisms of infertility, especially in women with milder forms of the disease. Treatment of endometriosis, including surgical ablation or resection, is cost-effective and offers the potential for improvement in cycle fecundity. Medical management of endometriosis-associated infertility has not been proven outside of in vitro fertilization.

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Condition tags

mesh:D004715mesh:D017699endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Endometriosis Endometriosis Endometriosis Evidence-Based Medicine Female Humans Infertility, Female Infertility, Female Infertility, Female Laparoscopy Pelvic Pain Pelvic Pain Pregnancy Prevalence Reproductive Techniques, Assisted Risk Factors Treatment Outcome

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (50)

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