Future Directions in Endometriosis Research

Thomas D'Hooghe, Thomas M D'Hooghe, Thomas D’Hooghe, C Kyama, Cleophas Kyama, S Debrock, Sophie Debrock, Christel Meuleman, C Meuleman, Jason M Mwenda
Annals of the New York Academy of Sciences · 2004 · vol. 1034(1) , pp. 316–325 · doi:10.1196/annals.1335.034 · W2156307934
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Future endometriosis research should focus on pathogenesis, early cell interactions, genomic and proteomic differences, and potential immunomodulatory drug treatments.

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Abstract

A bstract : Endometriosis is an important gynecological disease, pathologically defined by the ectopic presence of both endometrial glands and stroma, and clinically associated with pelvic pain and infertility. Our current knowledge of the pathogenesis, pathophysiology of related infertility, and spontaneous evolution is still limited, although endometriosis has been described for many years. Future research in endometriosis needs to focus on pathogenesis studies in the baboon model and on the early interactions between endometrial and peritoneal cells in the pelvic cavity at the time of menstruation. Proteomic and genomic approaches are needed to detect potential differences between eutopic endometrium and myometrium in women with and without endometriosis. Immunomodulatory drugs inhibiting endometriosis‐associated pelvic inflammation may offer new medical treatment for endometriosis in the future.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Genomics Reproductive Medicine Animals Endometriosis Endometriosis Endometriosis Female Genomics Humans Reproductive Medicine

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (60)

Cited by (31)

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