Effect of tumor necrosis factor-alpha on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system

Zhang RJ, Renjie Zhang, R J Zhang, R A Wild, Wild RA, Robert A. Wild, James M. Ojago, J M Ojago, Ojago JM
Fertility and sterility · 1993 · vol. 59(6) , pp. 1196–1201 · doi:10.1016/s0015-0282(16)55976-7 · PMID:8495765 · W2401679371
Lab / animal OA: closed CC0 ⤵ 106 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Tumor necrosis factor-α was investigated for its effect on the adhesion of human endometrial stromal cells to peritoneal mesothelial cells in an in vitro system.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To assess the effects of tumor necrosis factor-alpha (TNF-alpha) on adhesion of endometrial stromal cells to peritoneal mesothelial cells, a possible step leading to endometriosis. DESIGN: Analysis of cell adhesion in vitro. SETTING: University research laboratory. PATIENTS: Peritoneal fluid and biopsies were obtained from volunteers with regular cycles without endometriosis or endometrial pathology. INTERVENTIONS: Tumor necrosis factor-alpha (0.1 to 1,000 U/mL) was added to nutrient media with the following supplements: 10% fetal calf serum, epidermal growth factor 20 ng/mL, and gentamicin 10 ng/mL. MAIN OUTCOME MEASURES: Radioactivity of chromium-51 was used as a reflection of adherent stromal cells. RESULTS: The adherence of endometrial stromal cells to mesothelial cells was significantly increased by pretreatment of mesothelial cells with TNF-alpha. CONCLUSIONS: Tumor necrosis factor-alpha may play a facilitory role in the development of endometriosis.

My notes (saved in your browser only)

MeSH descriptors

Endometrium Peritoneal Cavity Stromal Cells Tumor Necrosis Factor-alpha Cell Adhesion Cell Adhesion Cell Adhesion Cells, Cultured Cells, Cultured Endometrium Endometrium Endometrium Epithelial Cells Epithelial Cells Female Female Humans Humans Peritoneal Cavity Peritoneal Cavity

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:59:37.277143+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK