Genomics' Role in Understanding the Pathogenesis of Endometriosis
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Abstract
Endometriosis is a benign, estrogen-dependent disorder that has multifactorial components presumed in its pathogenesis. The molecular mechanisms underlying endometrial tissue attachment to the peritoneal surface or metaplasia of the mesothelium, and subsequent invasion and establishment of a blood supply and survival of the endometriotic implants, are not well understood. Recent advances in molecular biology and genomics suggest an intrinsic abnormality in the eutopic endometrium of women with endometriosis that predisposes to these processes. These are discussed herein.
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Cited by (31)
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- The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis 2022
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- The Portuguese 35-item Survey of Pain Attitudes applied to Portuguese women with Endometriosis 2019
- Progesterone Resistance and Adult Stem Cells’ Genomic and Epigenetic Changes in the Puzzle of Endometriosis 2019
- Adult Stem Cells in the Pathogenesis and Treatment of Endometriosis 2017
- Hysteroscopic Findings in the Endometriosis Patient 2017
- DNA Microarray Analysis of Gene Expression in Eutopic Endometrium from Patients with Endometriosis 2017
- Endometriosis doubles odds for miscarriage in patients undergoing IVF or ICSI 2017
- Identifying biomarkers for non-invasive diagnosis of endometriosis 2016
- Intérêt actuel des selective progesterone receptor modulators (SPRM) dans l’endométriose 2013
- Endometrial Stem Cells and Endometriosis 2012
- Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis 2011
- Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma 2011
- Stem cells in endometrium and their role in the pathogenesis of endometriosis 2011
- Risk Factors for Endometriosis in a German Case–Control Study 2011
- Effect of the bone marrow derived-mononuclear stem cells transplantation in the growth, VEGF-R and TNF-alpha expression of endometrial implants in Wistar rats 2011
- Evolving Spectrum: 2010
- A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect 2010
- Faculty Opinions recommendation of A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect. 2010
- Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions 2007
- Imbalance in the expression of the activating type I and the inhibitory type II interleukin 1 receptors in endometriosis 2007
- Progesterone receptor modulators and the endometrium: changes and consequences† 2007
- Villar’s nodule: A case report and systematic literature review of endometriosis externa of the umbilicus 2007
- An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: A heterogeneous tissue with a complex disease 2006
- Endocrine Regulation of Menstruation 2005
- Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility 2005
- Endocrine Regulation of Menstruation 2005
- Immunology of endometriosis 2004
- Endometriose 2004
- Future Directions in Endometriosis Research 2004
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
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- pubmed
- last seen: 2026-05-13T22:12:50.257867+00:00
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