Polymorphism of the interleukin-1beta gene and endometriosis

F Wieser, Wieser F, Friedrich Wieser, Fritz Wieser, Lukas Hefler, Hefler L, Clemens Tempfer, Tempfer C, Vlach U, Ulli Vlach, Christian Schneeberger, Schneeberger C, Huber J, Johannes Huber, Rene Wenzl, Wenzl R
Journal of the Society for Gynecologic Investigation · 2003 · vol. 10(3) , pp. 172–175 · doi:10.1016/s1071-5576(03)00006-6 · PMID:12699881 · W2000614523
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This study investigated the association between variations in the Interleukin-1β gene and the occurrence of endometriosis.

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Abstract

OBJECTIVE: Experimental data indicate that interleukin (IL)-1 plays a role in the pathogenesis of endometriosis. We determined the genotype and the allele frequencies of the IL1B exon 5 polymorphism and the corresponding IL-1beta serum levels in women with endometriosis. METHODS: We genotyped 92 women with surgically and histologically confirmed endometriosis and 69 controls without history of endometriosis. Both groups were of middle European genetic background for the IL1B exon 5 polymorphism (at position +3954). Genotyping was performed by pyrosequencing. IL-1beta serum levels were analyzed by a commercially available enzyme-linked immunosorbent assay. RESULTS: Allele frequencies in women with endometriosis and controls were 76.6% and 76.8%, respectively, for the E1 allele (wild type) and 23.4% and 23.2%, respectively, for the E2 allele (polymorphic) (odds ratio 1.01; P > .99). The investigated polymorphism of the IL-1beta gene was not correlated with IL-1beta serum levels. CONCLUSIONS: We did not find an association between the IL1B exon 5 polymorphism, endometriosis, or increased serum IL-1beta levels.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-1 Polymorphism, Genetic Polymorphism, Genetic Alleles Alleles Endometriosis Endometriosis Exons Exons Female Female Gene Frequency Gene Frequency Genotype Genotype Humans Humans Interleukin-1 Interleukin-1

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