The association between endometriosis and polymorphisms in the interleukin-1 family genes in Korean women

Sungwook Chun, Chun S, Hoon Kim, Kim H, Ku SY, Seung‐Yup Ku, Seung-Yup Ku, Chang Suk Suh, Suh CS, Kim SH, Seok Hyun Kim, Kim JG, Jung Gu Kim
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 68(2) , pp. 154–163 · doi:10.1111/j.1600-0897.2012.01136.x · PMID:22509941 · W2046262574
Observational OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This study found an association between the IL-1R1 1498T>C polymorphism and early-stage endometriosis in Korean women, with lower serum sIL-1R2 levels observed in women with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

PROBLEM: To investigate the association between polymorphisms of the interleukin-1 (IL-1) family genes and endometriosis in Korean women. METHOD OF STUDY: In this case-control study, the IL-1α -889C>T, IL-1 receptor antagonist (IL-1RA) 86-bp microsatellite, IL-1 receptor 1 (IL-1R1) 52C>A, 294C>T, 1498T>C, 1632A>G, IL-1R2 rs2072472 C>T and rs7561460 C>T polymorphisms were analyzed in women with (n = 138) and without (n = 214) endometriosis using restriction fragment length polymorphism (RFLP) analysis, TaqMan assay, or DNA sequencing. Serum IL-1α, soluble IL-1RA (sIL-1RA), and sIL-1R2 levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Among the polymorphisms measured, the 1498T>C polymorphisms in the IL-1R1 gene were found to be related with early-stage endometriosis but not with advanced-stage endometriosis. The genotypes with at least one T allele (CT + TT) were less frequently observed in early-stage endometriosis compared with normal controls (OR = 0.44, 95% CI = 0.22-0.87, P = 0.02). Serum sIL-1R2 levels were significantly lower (P < 0.01) in women with endometriosis than in normal controls, whereas no difference in serum sIL-1RA levels between these two groups was noted. The single and haplotype genotypes of the IL-1R2 and IL-1RA microsatellite polymorphisms were not related with these serum levels. CONCLUSION: The IL-1R1 1498T>C polymorphism is associated with early-stage endometriosis in Korean women.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin 1 Receptor Antagonist Protein Polymorphism, Genetic Polymorphism, Genetic Receptors, Interleukin-1 Type I Receptors, Interleukin-1 Type II Adult Adult Case-Control Studies Case-Control Studies Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Endometriosis Female Female Genetic Association Studies Genetic Association Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (37)

Cited by (11)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:10:13.363893+00:00
License: CC0 · commercial use OK