Is There a Genetic Basis to Endometriosis?

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Abstract

It is likely that endometriosis is a common multifactorial disease, like diabetes and asthma, caused by an interaction between multiple gene loci and the environment. Such conditions do not have a clear Mendelian pattern of inheritance. This chapter reviews the existing evidence, in human and non-human primates, that suggests there is a genetic basis to endometriosis. The environmental agents that have been implicated in the development of endometriosis are also reviewed. The identification of genetic loci conferring susceptibility to endometriosis using linkage analysis may lead to a better understanding of disease aetiology and, in time, improved therapeutic strategies and diagnostic methods.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Genetic Linkage Animals Endometriosis Endometriosis Endometriosis Environmental Pollutants Environmental Pollutants Female Humans Immunity, Cellular Karyotyping Loss of Heterozygosity Macaca mulatta Macaca mulatta Mullerian Ducts Mullerian Ducts Pedigree Phenotype

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Cited by (31)

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europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:52.568893+00:00
License: CC0 · commercial use OK