Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose–response manner: a randomized, double-blind, placebo-controlled study

Yutaka Osuga, Yoshifumi Seki, Masataka Tanimoto, Takeru Kusumoto, Kentarou Kudou, Naoki Terakawa
Fertility and sterility · 2020 · vol. 115(2) , pp. 397–405 · doi:10.1016/j.fertnstert.2020.07.055 · PMID:32912633 · W3083548215
article OA: closed CC0 ⤵ 53 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This randomized, double-blind, placebo-controlled study found that the oral GnRH receptor antagonist relugolix effectively reduced endometriosis-associated pain in a dose-dependent manner.

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Androgen Antagonists Endometriosis Pain Measurement Pelvic Pain Phenylurea Compounds Pyrimidinones Receptors, LHRH Administration, Oral Adult Androgen Antagonists Dose-Response Relationship, Drug Double-Blind Method Endometriosis Endometriosis Female Humans Middle Aged Pain Measurement Pain Measurement Pelvic Pain

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europepmc
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openalex
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License: CC0 · commercial use OK