Intervention of Phytochemicals During Endometriosis and Their Conceivable Mechanisms

Endometriosis is a chronic and complex endocrine disorder that affects women of reproductive age. This syndrome is benign and is characterized by a combination of ovarian dysfunction and estrogen dependency symptoms, as well as pain and infertility. The most commonly stated symptoms include dysmenorrhea, significant dyspareunia, dyschezia, and dysuria. It is a severe public health issue. The prevalence rate is quite high and continues to rise on a daily basis. Starting with its diagnosis, pathophysiology, repercussions, and treatment options, there are numerous areas of disagreement. This study aims to provide an overview of the development of endometriosis diagnosis, symptoms, risk factors, etiology, medicinal plants, phytochemicals, and treatment, with a focus on research and the creation of novel therapeutic strategies. We conclude by making predictions and recommendations for the future of endometriosis-related research and prospective therapy approaches. Graphical Abstract Similar content being viewed by others Change history 17 August 2023 A Correction to this paper has been published: https://doi.org/10.1007/s43450-023-00444-0

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N Engl J Med 382:1244–1256. https://doi.org/10.1056/NEJMra1810764 Funding This study was supported by the Indian Council of Medical Research (ICMR: Grant No. 2021-15004) and by Institution of Eminence (IoE), Banaras Hindu University (Seed Grant). Author information Authors and Affiliations Contributions SA and AS equally contributed to the design and draft of the manuscript; JC and VP contributed in the correction of the text; PKD and AT contributed to the conception and design of the research study. GT contributed to draw the chemical structure of phytochemicals. All authors revised and approved the final manuscript before submission. Corresponding author Additional information The original online version of this article was revised: The graphical abstract was corrected. Supplementary Information Below is the link to the electronic supplementary material. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Ayesha, S., Sharma, A., Chauhan, J.K. et al. Intervention of Phytochemicals During Endometriosis and Their Conceivable Mechanisms. Rev. Bras. Farmacogn. 33, 1126–1140 (2023). https://doi.org/10.1007/s43450-023-00426-2 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s43450-023-00426-2