Clinical diagnosis of endometriosis: a call to action

Sanjay K Agarwal; Charles Chapron; Linda C Giudice; Marc R Laufer; Nicholas Leyland; Stacey A Missmer; Sukhbir S Singh; Hugh S Taylor

doi:10.1016/j.ajog.2018.12.039

Clinical diagnosis of endometriosis: a call to action

Sanjay K Agarwal, Charles Chapron, Linda C Giudice, Marc R Laufer, Nicholas Leyland, Stacey A Missmer, Sukhbir S Singh, Hugh S Taylor

American journal of obstetrics and gynecology · 2019 · vol. 220(4) , pp. 354.e1–354.e12 · doi:10.1016/j.ajog.2018.12.039 · PMID:30625295 · W2907530084

article OA: bronze CC0 ⤵ 585 in-corpus citations

🔓 Open OA copy View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper addresses the critical need for improved clinical diagnosis of endometriosis, advocating for urgent action to advance diagnostic methods and patient care.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004412mesh:D004414mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Chronic Pain Dysmenorrhea Dyspareunia Endometriosis Infertility, Female Pelvic Pain Chronic Pain Chronic Pain Delayed Diagnosis Dysmenorrhea Dysmenorrhea Dyspareunia Dyspareunia Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female

Funding

funders: [{'doi': '10.13039/100007819', 'name': 'Allergan', 'awards': []}, {'doi': '10.13039/100000002', 'name': 'National Institutes of Health', 'awards': []}, {'doi': '10.13039/100013733', 'name': 'Ipsen Biopharmaceuticals', 'awards': []}, {'doi': '10.13039/100004334', 'name': 'Merck', 'awards': []}, {'doi': '10.13039/100015340', 'name': 'Bayer Fund', 'awards': []}, {'doi': '10.13039/501100000024', 'name': 'Canadian Institutes of Health Research', 'awards': []}, {'doi': '10.13039/501100003358', 'name': 'Gedeon Richter', 'awards': []}, {'doi': '10.13039/100006483', 'name': 'AbbVie', 'awards': []}]

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

crossref: last seen: 2026-05-17T01:00:02.040995+00:00
europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:23:01.605684+00:00

License: CC0 · commercial use OK

[1] A clinical score can predict associated deep infiltrating endometriosis before surgery for an endometrioma via crossref

[2] Anterior Vaginal Wall Tenderness (AVWT) as a Physical Symptom in Chronic Pelvic Pain via crossref

[3] Anterior Vaginal Wall Tenderness (AVWT) as a Physical Symptom in Chronic Pelvic Pain via openalex

[4] Association between chronic pelvic pain symptoms and the presence of endometriosis via crossref

[5] Association between chronic pelvic pain symptoms and the presence of endometriosis via openalex

[6] Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients via openalex

[7] Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients via crossref

[8] Association between surgically diagnosed endometriosis and adverse pregnancy outcomes via crossref

[9] Association between surgically diagnosed endometriosis and adverse pregnancy outcomes via openalex

[10] Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1 via openalex

[11] Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1 via crossref

[12] Characteristics of Women with Endometriosis from the USA and Puerto Rico via openalex

[13] Circulating microRNAs as potential biomarkers for endometriosis via openalex

[14] Circulating microRNAs as potential biomarkers for endometriosis via crossref

[15] Combination of transvaginal sonography and clinical examination for preoperative diagnosis of pelvic endometriosis via openalex

[16] Combination of transvaginal sonography and clinical examination for preoperative diagnosis of pelvic endometriosis via crossref

[17] Consensus on current management of endometriosis via openalex

[18] Consensus on current management of endometriosis via crossref

[19] Correlation of anterior vaginal wall pain with endometriosis in infertile patients. via openalex

[20] Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study via crossref

[21] Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study via openalex

[22] Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis via crossref

[23] Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis via openalex

[24] Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences via crossref

[25] Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences via openalex

[26] Diagnostic Delay of Endometriosis in the Netherlands via openalex

[27] Diagnostic Delay of Endometriosis in the Netherlands via crossref

[28] Endometriosis: a high-risk population for major chronic diseases? via crossref

[29] Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice† via openalex

[30] Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice† via crossref

[31] Endometriosis and obstetrics complications: a systematic review and meta-analysis via crossref

[32] Endometriosis and obstetrics complications: a systematic review and meta-analysis via openalex

[33] Endometriosis: Diagnosis and Management via crossref

[34] Endometriosis: Diagnosis and Management via openalex

[35] Endometriosis diagnosis and staging by operating surgeon and expert review using multiple diagnostic tools: an inter‐rater agreement study via crossref

[36] Endometriosis diagnosis and staging by operating surgeon and expert review using multiple diagnostic tools: an inter‐rater agreement study via openalex

[37] Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion via openalex

[38] Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion via crossref

[39] Endometriosis increases the risk of obstetrical and neonatal complications via crossref

[40] ESHRE guideline: management of women with endometriosis via crossref

[41] Evaluation of Risk Factors Associated with Endometriosis in Infertile Women. via openalex

[42] Factors Associated with Time to Endometriosis Diagnosis in the United States via openalex

[43] Factors Associated with Time to Endometriosis Diagnosis in the United States via crossref

[44] High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via crossref

[45] High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via openalex

[46] History, pelvic examination findings and mobility of ovaries as a sonographic marker to detect pelvic adhesions with fixed ovaries via openalex

[47] History, pelvic examination findings and mobility of ovaries as a sonographic marker to detect pelvic adhesions with fixed ovaries via crossref

[48] Imaging modalities for the non-invasive diagnosis of endometriosis via openalex

[49] Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via crossref

[50] Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via openalex

[51] Impact of endometriosis on women’s lives: a qualitative study via openalex

[52] Impact of endometriosis on women’s lives: a qualitative study via crossref

[53] Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study via crossref

[54] Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study via openalex

[55] Increased Pressure Pain Sensitivity in Women With Chronic Pelvic Pain via crossref

[56] Increased Pressure Pain Sensitivity in Women With Chronic Pelvic Pain via openalex

[57] Incremental direct and indirect cost burden attributed to endometriosis surgeries in the United States via openalex

[58] Incremental direct and indirect cost burden attributed to endometriosis surgeries in the United States via crossref

[59] Laparoscopic Excision of Lesions Suggestive of Endometriosis or Otherwise Atypical in Appearance: Relationship Between Visual Findings and Final Histologic Diagnosis via openalex

[60] Laparoscopic Excision of Lesions Suggestive of Endometriosis or Otherwise Atypical in Appearance: Relationship Between Visual Findings and Final Histologic Diagnosis via crossref

[61] Markers of deep infiltrating endometriosis in patients with ovarian endometrioma: a predictive model via crossref

[62] Obstetrical Complications in Women with Endometriosis: A Cohort Study in Japan via crossref

[63] Pain typology and incident endometriosis via openalex

[64] Pain typology and incident endometriosis via crossref

[65] Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms via openalex

[66] Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms via crossref

[67] Practice Bulletin No. 114: Management of Endometriosis via crossref

[68] Practice Bulletin No. 114: Management of Endometriosis via openalex

[69] Premenstrual spotting of ≥2 days is strongly associated with histologically confirmed endometriosis in women with infertility via crossref

[70] Premenstrual spotting of ≥2 days is strongly associated with histologically confirmed endometriosis in women with infertility via openalex

[71] Prevalence and Symptomatic Burden of Diagnosed Endometriosis in the United States: National Estimates from a Cross-Sectional Survey of 59,411 Women via openalex

[72] Prevalence and Symptomatic Burden of Diagnosed Endometriosis in the United States: National Estimates from a Cross-Sectional Survey of 59,411 Women via crossref

[73] Progression of Endometriosis in Non-medically Managed Adolescents: A Case Series via openalex

[74] Progression of Endometriosis in Non-medically Managed Adolescents: A Case Series via crossref

[75] Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States via openalex

[76] Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States via crossref

[77] Retreatment Rates Among Endometriosis Patients Undergoing Hysterectomy or Laparoscopy via crossref

[78] Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO Study via openalex

[79] Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO Study via crossref

[80] Self‐reported prevalence of endometriosis and its symptoms among Puerto Rican women via openalex

[81] Self‐reported prevalence of endometriosis and its symptoms among Puerto Rican women via crossref

[82] Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis via openalex

[83] Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis via crossref

[84] Spectrum of symptoms in women diagnosed with endometriosis during adolescence vs adulthood via crossref

[85] Surgery for endometriosis: beyond medical therapies via crossref

[86] Surgery for endometriosis: beyond medical therapies via openalex

[87] Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group via crossref

[88] Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group via openalex

[89] The Effect of Endometriosis Symptoms on Absenteeism and Presenteeism in the Workplace and at Home via openalex

[90] The social and psychological impact of endometriosis on women's lives: a critical narrative review via openalex

[91] The social and psychological impact of endometriosis on women's lives: a critical narrative review via crossref

[92] Transvaginal sonography in the diagnosis of deep infiltrating endometriosis: A review via crossref

[93] Transvaginal sonography in the diagnosis of deep infiltrating endometriosis: A review via openalex

[94] Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis via crossref

[95] Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis via openalex

[96] Treatment of pelvic pain associated with endometriosis: a committee opinion via openalex

[97] Treatment of pelvic pain associated with endometriosis: a committee opinion via crossref

[98] Treatment Patterns, Complications, and Health Care Utilization Among Endometriosis Patients Undergoing a Laparoscopy or a Hysterectomy: A Retrospective Claims Analysis via crossref

[99] Treatment Patterns, Complications, and Health Care Utilization Among Endometriosis Patients Undergoing a Laparoscopy or a Hysterectomy: A Retrospective Claims Analysis via openalex

[100] Update on Biomarkers for the Detection of Endometriosis via openalex