Endometriosis and menopause—management strategies based on clinical scenarios

Ivika Jakson, Angelica Lindén Hirschberg, Sebastian Gidlöf
Acta obstetricia et gynecologica Scandinavica · 2023 · vol. 102(10) , pp. 1323–1328 · doi:10.1111/aogs.14583 · PMID:37186303 · W4367188779
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review discusses managing endometriosis symptoms in peri- and postmenopausal women, emphasizing careful consideration of menopausal hormone therapy due to estrogen dependency and potential risks like recurrence or malignant transformation.

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Abstract

Endometriosis is largely considered a premenopausal disease with symptoms often improving during menopausal transition. However, 2%-4% of postmenopausal women are affected by endometriosis symptoms. At the same time, many peri- and postmenopausal women experience menopausal symptoms and inquire about treatment. Because of the estrogen-dependent nature of endometriosis, treatment with menopausal hormone therapy requires careful assessment of the patient but should nevertheless be considered. Recurrence of endometriosis symptoms and risk for malignant transformation are potential risks to weigh when prescribing menopausal hormonal therapy. Choice of treatment should be guided by the presence and severity of current endometriosis symptoms, nature of menopausal symptoms, risk assessment of potential contraindications for treatment in patient history, and preferences of the woman after an informative discussion. Recurrence of endometriosis symptoms in a postmenopausal patient should always prompt rigorous evaluation, both in the presence and absence of hormonal treatment. Many recommendations on the topic are based on expert opinion and new studies are urgently needed to obtain evidence for optimal patient care.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogen Replacement Therapy Female Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (7)

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