A comparison of nafarelin acetate and danazol in the treatment of endometriosis

S H Kennedy, Kennedy SH, Stephen Kennedy, Williams IA, I A Williams, Iola A. Williams, J Brodribb, Brodribb J, James Brodribb, Barlow DH, D H Barlow, David H. Barlow, Robert W. Shaw, R W Shaw, Shaw RW
Fertility and sterility · 1990 · vol. 53(6) , pp. 998–1003 · doi:10.1016/s0015-0282(16)53574-2 · PMID:2140996 · W2416107681
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This study compared the efficacy of nafarelin acetate and danazol in treating endometriosis patients.

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Abstract

Nafarelin 400 micrograms daily and danazol 600 mg daily were compared in a double-blind randomized study. Eighty-two patients with endometriosis were treated for 6 months after an initial laparoscopy and 74 had a second laparoscopy. Twenty-two (30%) patients had complete disease regression, 42 (57%) patients had a partial regression, and in 10 (13%) patients disease was unchanged or worse. Both treatments led to significant regression of active disease but not of adhesions. At 3 months follow-up, 34 (64%) patients reported their symptoms were improved, 15 (28%) reported no change, and 4 (8%) were worse. Nafarelin was associated with more hot flushes and headaches, and danazol with more weight gain. No significant differences, however, were noted in treatment efficacy between the two groups.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Gonadotropin-Releasing Hormone Pregnadienes Uterine Neoplasms Adult Adult Amenorrhea Amenorrhea Amenorrhea Analysis of Variance Analysis of Variance Danazol Danazol Danazol Double-Blind Method Double-Blind Method Endometriosis Endometriosis Estradiol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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