Robert W. Shaw

Biopsy may be necessary with the non-pigmented and opacified implants to confirm the diagnosis. The surgeon should look for bluish-black implants or papules varying in colour on or under the peritoneal surface, and for deep infiltrating imp…

The human endometrial epithelium is pivotal to menstrual cycle progression, implantation and early pregnancy. Endometrial function is directly regulated by local factors that include pH, oxygen tension and ion concentrations to generate an …

STUDY QUESTION: What is the current management of women with ovarian endometriomas undergoing assisted reproductive treatment (ART) in the UK? SUMMARY ANSWER: It appears that the majority of gynaecologists in the UK offer surgery (mostly c…

The skeletal effects of two therapies for endometriosis that produce hypo-oestrogenism in 23 premenopausal women have been studied. Eleven women received goserelin 3.6 mg monthly by subcutaneous implant and 12 women received danazol 600 mg …

Plasma lipid risk markers for coronary heart disease (CHD) are influenced by sex steroid concentrations. Therapies that alter sex hormone levels have the potential to affect CHD risk. Zoladex had no effect on plasma lipids, but increased hi…

There have been few appropriately conducted trials to evaluate the effectiveness of laser destruction of endometriosis in relieving pain symptoms, yet the techniques are increasingly being used. Laser destruction has been shown to be more e…

ABSTRACT We report a case of an endometrioma in a laparoscopic port scar, an unusual possible complication of laparoscopic surgery. The patient presented with typical features of a scar endometrioma and the lesion was surgically excised. La…

Objective To determine whether goserelin (Zoladex TM ; AstraZeneca, London, UK), plus surgery offers advantages over surgery alone in the management of ovarian endometriomas. Design Prospective, multicentre, randomized, open‐label, parallel…

OBJECTIVE: To determine the duration of time to the recurrence of pain attributable to endometriosis after the discontinuation of treatment with danazol or a GnRH agonist (GnRH-a) in patients who have had a satisfactory response to the trea…

Objective: To investigate possible risk factors for the development of endometriosis. Study Design: A case control study of 147 women with a new diagnosis of endometriosis, and 131 normal controls recruited from well women clinics. Controls…

OBJECTIVE: To assess whether tibolone can prevent the bone loss and symptomatic side effects normally associated with GnRH agonist (GnRH-a) use and whether tibolone modifies the effect of GnRH-a on endometriosis. DESIGN: Prospective, doubl…

Part 1 Cellular pathophysiology: pathogenesis and aetiology - questions, questions, questions morphology, ultrastructure and receptors in untreated and treated endometriotic implants morphology of the implant - two- and three-dimensional ev…

Cyclical ultrastructural changes in the endometrium and Fallopian tube have been reported previously but in different subjects. The aim of this study is to compare cyclical changes in endometrial gland and tubal (isthmic, mid-tube, ampulla,…

Medical treatments of endometriosis rely upon the hormonal dependence of endometriotic implants for further growth and extension. The cyclic nature of the symptoms means they may be helped by agents that suppress menstruation both from the …

Although usually not life-threatening, dysfunctional uterine bleeding (DUB) can cause discomfort and disruption to life for many women. It has been poorly researched in the past, primarily because of difficulties in trying to accurately mea…

OBJECTIVE: Our purpose was to compare the efficacy of the recommended dose of danazol, a reduced-dose danazol regimen, and norethindrone in the treatment of objectively proven menorrhagia. Recurrence after discontinuing treatment was also a…

OBJECTIVE: To test the effect of peritoneal fluid from infertile women with minimal or mild endometriosis on sperm movement characteristics in comparison with fertile and infertile women with no endometriosis. DESIGN: A prospective observe…

Gonadotropin-releasing hormone analogues (GnRH-a) were first used in the treatment of endometriosis in 1982. Large-scale clinical trials with these agents have now been completed. All of the analogue studies have shown them to be as effecti…

To assess the effect of GnRH pretreatment prior to IVF-ET on fertilisation and pregnancy rates in patients with endometriosis compared with tubal infertility, a retrospective analysis of 228 cycles of tubal infertility cases (Group 1) and 9…