Treatment of endometriosis with an antigonadotropin, Danazol. A laparoscopic and histologic evaluation.

W. Paul Dmowski, W P Dmowski, Cohen Mr, M R Cohen
Obstetrics and gynecology · 1975 · vol. 46(2) , pp. 147–54 · PMID:125397 · W2407712969
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Danazol treatment of 39 endometriosis patients resulted in ovarian suppression and a marked decrease in disease extent, with 59% showing no evidence of disease post-treatment.

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Abstract

Antigonadotropin (Danazol) was administered to 39 patients with endometriosis diagnosed at laparoscopy and confirmed by laparoscopic biopsy. None of the patients had surgical resection of the lesion prior to the treatment. While on the drug, all patients developed evidence of ovarian suppression both in regard to ovulation and steroidogenesis. The results were evaluated by repeat laparoscopy and biopsy. The extent of the disease was documented before and after treatment by photography and drawing. There was marked decrease in the extent of endometriosis after treatment: 59% of patients had no evidence of disease, 26% had peritoneal adhesions and hemosiderin deposits but no active endometriosis, and 15% had residual endometriosis. Histology in the latter group revealed atrophic changes in the uterine and ectopic endometrium and the evidence of a healing process.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Danazol Endometriosis Ovarian Neoplasms Pregnadienes Biopsy Danazol Danazol Danazol Endometriosis Endometriosis Endoscopy Female Humans Laparoscopy Ovarian Neoplasms Pregnadienes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (50)

SciLite annotations

chemicals 2
danazol danazol

Source provenance

europepmc
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