Comparison of Ovulation Induction Protocols After Endometrioma Resection

Ercan Bastu, Ercan Baştu, Cenk Yasa, Cenk Yaşa, Ozlem Dural, Özlem Dural, Mehmet Fırat Mutlu, Mehmet Firat Mutlu, Cem Celik, Cem Çeli̇k, Funda Güngör Uğurlucan, Funda Gungor Ugurlucan, Faruk Buyru
JSLS : Journal of the Society of Laparoendoscopic Surgeons · 2014 · vol. 18(3) , pp. e2014.00128 · doi:10.4293/jsls.2014.00128 · PMID:25392665 · W2323872123
article OA: hybrid CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that the long GnRH-a protocol resulted in more follicles and oocytes than the GnRH-ant protocol, but pregnancy rates were similar between groups after endometrioma resection.

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Abstract

BACKGROUND AND OBJECTIVES: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. METHODS: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n=44), and those who had ovarian stimulation with a GnRH-ant protocol (n=42). RESULTS: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive β-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P=.269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P=.302) between the 2 protocols. CONCLUSIONS: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Endometriosis Fertilization in Vitro Gonadotropin-Releasing Hormone Leuprolide Ovulation Induction Postoperative Care Triptorelin Pamoate Adolescent Adult Endometrial Neoplasms Endometrial Neoplasms Endometriosis Female Fertility Agents, Female Fertility Agents, Female Fertilization in Vitro Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Leuprolide

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